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Gene · 4159

MC3R: melanocortin 3 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MC3R: melanocortin 3 receptor. Genes, record 4159. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4159

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Gene

Symbol
MC3R
HGNC
Name
melanocortin 3 receptor
HGNC
NCBI Gene ID
4159
NCBI Gene
HGNC ID
HGNC:6931
HGNC
Ensembl
ENSG00000124089
NCBI Gene
Aliases
BMIQ9, MC3, MC3-R, OB20, OQTL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41968Melanocortin receptor 33236Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4777830 A12026-07-2213P41968Espacenet
JP 2025529142 A2025-09-042570P41968Espacenet
US 12371689 B22025-07-292570P41968Espacenet
US 11446398 B22022-09-2050032P41968Espacenet
US 11400116 B22022-08-027386P41968Espacenet
JP 2022524081 A2022-04-27153003P41968Espacenet
US 11078247 B22021-08-036648P41968Espacenet
US 10772934 B22020-09-151291P41968Espacenet
US 9951337 B22018-04-2438P41968Espacenet
US 9878056 B22018-01-301498P41968Espacenet

1 to 10 of 22

See all 22 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
MODIMELANOTIDECHEMBL3545104Melanocortin receptor 3 agonistAGONIST

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants756

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMC3R papersNewest fiscal year
ZIAHD000641Physiology, Psychology, and Genetics of Obesity112025
P30CA016672Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant62025
P30DK020572Michigan Diabetes Research Center (MDRC)62025
P30CA056036Translational Research in Cancer42025
P30DK026687New York Obesity Research Center42025
P30DK072476Pennington/Louisiana NORC42025
T32GM008562Clinical Pharmacology Training Program42025
P30CA076292Moffitt Cancer Center Support Grant32025
P50HD104224The Massachusetts General Hospital Harvard Center for Reproductive Medicine32025

1 to 10 of 756Source NIH's project files

See all 756 nih grants

Papers1,260

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Sex-specific control of feeding and defensive behaviors by MC3R neurons in the bed nuclei of the stria terminalis.bioRxiv202642745757PubTator, text miningPubMed
Neural Melanocortin Receptors in Fish: Insights into Growth Regulation and Aquaculture Advancement.Biomolecules202642352306PubTator, text miningPubMed
A Dimer for Dinner: The Impact of GHS-R1a Heterodimerization on Feeding Circuits.Biomolecules202642352256PubTator, text miningPubMed
Goldilocks-Inspired Design of Mid-Size Macrocycles for Selective Targeting of Human Melanocortin Receptors.J Med Chem202642340853PubTator, text miningPubMed
Sex-differential associations of MC3R p.F45S with human metabolic profile.J Neuroendocrinol202642303965PubTator, text miningPubMed
Thermodynamic selectivity and kinetic control in the encapsulation of spiropyran derivatives by cucurbit[8]uril.Phys Chem Chem Phys202642300686PubTator, text miningPubMed
Regulators of Appetite in Mammals - Old and New players.Endocr Rev202642274231PubTator, text miningPubMed
Dual activation of MC3R and MC4R drives weight loss and reduces food intake in male primates with obesity.Nat Commun202642215442PubTator, text miningPubMed
The Necessity of POMC and MC3R Analysis in the First-Level Diagnosis of Monogenic Obesity: The Experience of Two Italian Centers.Genes (Basel)202642074523PubTator, text miningPubMed
Diverse ring architectures of cyclic peptidomimetics targeting melanocortin receptors.RSC Med Chem202642037742PubTator, text miningPubMed

1 to 10 of 1,260

See all 1,260 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4159

GET https://conductscience.org/api/genes/v1/4159/patents?page=2