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MC4R: melanocortin 4 receptor

1 protein, 37 patents, 5 drugs, 28 trials, 3,015 NIH grants and 4,700 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMC4RHGNC
Namemelanocortin 4 receptorHGNC
NCBI Gene ID4160NCBI Gene
HGNC IDHGNC:6932HGNC
EnsemblENSG00000166603NCBI Gene
AliasesBMIQ20NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P32245Melanocortin receptor 433212Ensembl, GeneID, HGNCUniProt

Patents 37

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777830 A12026-07-2214P32245Espacenet
WO 2025238358 A12025-11-2010P32245Espacenet
EP 4640849 A22025-10-29514P32245Espacenet
EP 4641201 A22025-10-293538P32245Espacenet
JP 2025131693 A2025-09-0913P32245Espacenet
JP 2025529142 A2025-09-042571P32245Espacenet
US 12371689 B22025-07-292571P32245Espacenet
JP 2025519096 A2025-06-24514P32245Espacenet
JP 2025517969 A2025-06-123538P32245Espacenet
EP 4541896 A12025-04-23273P32245Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BREMELANOTIDECHEMBL2070241Melanocortin receptor 4 agonistAGONISTChEMBL
BREMELANOTIDE ACETATECHEMBL4297533Melanocortin receptor 4 agonistAGONISTChEMBL
PF-00446687CHEMBL1090488Melanocortin receptor 4 agonistAGONISTChEMBL
SETMELANOTIDECHEMBL3301624Melanocortin receptor 4 agonistAGONISTChEMBL
SETMELANOTIDE ACETATECHEMBL4650273Melanocortin receptor 4 agonistAGONISTChEMBL

Trials 28

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07496463SETMELANOTIDEPHASE2ClinicalTrials.gov
NCT06772597SETMELANOTIDEPHASE2ClinicalTrials.gov
NCT06596135SETMELANOTIDEPHASE3ClinicalTrials.gov
NCT06565611BREMELANOTIDEPHASE2ClinicalTrials.gov
NCT05774756SETMELANOTIDEPHASE3ClinicalTrials.gov
NCT05709444BREMELANOTIDEPHASE2ClinicalTrials.gov
NCT05194124SETMELANOTIDEPHASE32024-11-26ClinicalTrials.gov
NCT05183802SETMELANOTIDEClinicalTrials.gov
NCT05093634SETMELANOTIDEPHASE3ClinicalTrials.gov
NCT04966741SETMELANOTIDEPHASE32024-07-10ClinicalTrials.gov

NIH grants 3015

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020572Michigan Diabetes Research Center (MDRC)352,025NIH's project files
P30DK063491Diabetes Research Center (DRC)212,025NIH's project files
R01DK075787Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum202,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal182,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)172,025NIH's project files
P30DK026687New York Obesity Research Center172,025NIH's project files
ZIADK069028Genetic Epidemiology of Diabetes and Obesity172,025NIH's project files
ZIADK069071Structural Analysis Of Candidate Genes For Type 2 Diabetes and Obesity172,025NIH's project files
ZIAHD000641Physiology, Psychology, and Genetics of Obesity172,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility152,025NIH's project files

Papers 4700

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821228PubTator, text miningPubMed
42819174PubTator, text miningPubMed
42791368PubTator, text miningPubMed
42743093PubTator, text miningPubMed
42724349PubTator, text miningPubMed
42723356PubTator, text miningPubMed
42708306PubTator, text miningPubMed
42703854PubTator, text miningPubMed
42697206PubTator, text miningPubMed
42660416PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license