ConductScience.org, home

Library / Genes

MCL1: MCL1 apoptosis regulator, BCL2 family member

1 protein, 101 patents, 2 drugs, 19 trials, 6,843 NIH grants and 19,499 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMCL1HGNC
NameMCL1 apoptosis regulator, BCL2 family memberHGNC
NCBI Gene ID4170NCBI Gene
HGNC IDHGNC:6943HGNC
EnsemblENSG00000143384NCBI Gene
AliasesBCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EATNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q07820Induced myeloid leukemia cell differentiation protein Mcl-1350143Ensembl, GeneID, HGNCUniProt

Patents 101

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4782537 A12026-07-293Q07820Espacenet
JP 2026086637 A2026-05-2680Q07820Espacenet
JP 2026004568 A2026-01-1454412Q07820Espacenet
JP 2025541604 A2025-12-2283Q07820Espacenet
JP 2025183333 A2025-12-1671Q07820Espacenet
EP 4650780 A22025-11-198547Q07820Espacenet
US 12466853 B22025-11-1180Q07820Espacenet
EP 4640849 A22025-10-291291Q07820Espacenet
EP 4641201 A22025-10-298713Q07820Espacenet
KR 1020250144510 A2025-10-1083Q07820Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
OBATOCLAXCHEMBL408194Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitorINHIBITORChEMBL
OBATOCLAX MESYLATECHEMBL2107358Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitorINHIBITORChEMBL

Trials 19

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01563601OBATOCLAX MESYLATEPHASE3ClinicalTrials.gov
NCT01238146OBATOCLAX MESYLATEPHASE1/PHASE2ClinicalTrials.gov
NCT00933985OBATOCLAX MESYLATEPHASE1ClinicalTrials.gov
NCT00918931OBATOCLAX MESYLATEPHASE22011-04-25ClinicalTrials.gov
NCT00724841OBATOCLAX MESYLATEPHASE1/PHASE2ClinicalTrials.gov
NCT00719901OBATOCLAX MESYLATEPHASE1/PHASE22013-12-09ClinicalTrials.gov
NCT00684918OBATOCLAXPHASE2ClinicalTrials.gov
NCT00682981OBATOCLAXPHASE1/PHASE2ClinicalTrials.gov
NCT00612612OBATOCLAX MESYLATEPHASE1ClinicalTrials.gov
NCT00600964OBATOCLAX MESYLATEPHASE1ClinicalTrials.gov

NIH grants 6843

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2922,025NIH's project files
P30CA008748Cancer Center Support Grant1072,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant502,025NIH's project files
P30CA016058Cancer Center Support Grant472,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant472,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)462,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant352,025NIH's project files
P30CA047904Cancer Center Support Grant332,025NIH's project files
P30CA068485Cancer Center Support Grant292,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology282,025NIH's project files

Papers 19499

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821605PubTator, text miningPubMed
42817838PubTator, text miningPubMed
42806156PubTator, text miningPubMed
42798295PubTator, text miningPubMed
42794479PubTator, text miningPubMed
42793017PubTator, text miningPubMed
42789493PubTator, text miningPubMed
42778648PubTator, text miningPubMed
42776347PubTator, text miningPubMed
42760486PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license