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Gene · 4171

MCM2: minichromosome maintenance complex component 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MCM2: minichromosome maintenance complex component 2. Genes, record 4171. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4171

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Gene

Symbol
MCM2
HGNC
Name
minichromosome maintenance complex component 2
HGNC
NCBI Gene ID
4171
NCBI Gene
HGNC ID
HGNC:6944
HGNC
Ensembl
ENSG00000073111
NCBI Gene
Aliases
BM28, CCNL1, CDCL1, D3S3194, DFNA70, KIAA0030, MITOTIN, cdc19
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49736DNA replication licensing factor MCM290439Ensembl, GeneID, HGNC

Source UniProt

Patents62

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192429P49736Espacenet
EP 4641201 A22025-10-292013P49736Espacenet
EP 4641202 A22025-10-294587P49736Espacenet
WO 2025163163 A12025-08-071P49736Espacenet
JP 2025517969 A2025-06-122013P49736Espacenet
JP 2025517970 A2025-06-122429P49736Espacenet
KR 1020250017231 A2025-02-044587P49736Espacenet
JP 2024123008 A2024-09-107007P49736Espacenet
JP 2023123507 A2023-09-0514P49736Espacenet
US 11446398 B22022-09-2051674P49736Espacenet

1 to 10 of 62

See all 62 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,980

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMCM2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant222025
P30CA008748Cancer Center Support Grant212025
P30CA016056Roswell Park Cancer Center Support Grant152025
P30CA014051Cancer Center Support (Core) Grant102025
P30CA016086Cancer Center Support Grant92025
R01GM045436Initiation of DNA Replication at Cell Origins in Yeast92025
P30CA076292Moffitt Cancer Center Support Grant82025
R35GM118015Mechanism of Epigenetic Inheritance82025
P30CA013330Cancer Center Support Grant72025
P30CA045508CSHL Cancer Center Support Grant72025

1 to 10 of 1,980Source NIH's project files

See all 1,980 nih grants

Papers3,775

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation.Nat Commun202642733061PubTator, text miningPubMed
Brusatol Triggers Cell Cycle Arrest and Apoptosis, Disrupts Sterol Biosynthesis, and Enhances the Anti-Leukemic Activity of Venetoclax in AML Cells.Cell Biochem Biophys202642711651PubTator, text miningPubMed
Suppression of MCM2 reduces cancer stem cells and epithelial-mesenchymal transition-related phenotypes in breast cancer cells.Korean J Clin Oncol202642687515PubTator, text miningPubMed
Evaluation of the clinical and mechanistic role of MCM2 expression in the prediction of meningioma recurrence after radiotherapy.Neurosurg Focus202642679387PubTator, text miningPubMed
MCM2 and p53 Expression Correlate with the Spectrum of Mucinous Ovarian Tumor.Asian Pac J Cancer Prev202642663211PubTator, text miningPubMed
A nomogram model integrating transcriptomics and clinical features for predicting the risk of cervical intraepithelial lesion progression.Front Oncol202642656450PubTator, text miningPubMed
Nat10-mediated ac4C modification sustains macrophage proliferation and mitigates colitis progression via Mcm2 stabilization.Sci China Life Sci202642645676PubTator, text miningPubMed
A complex mutational signature generated by cytarabine resistance.NAR Cancer202642630438PubTator, text miningPubMed
Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.iScience202642620746PubTator, text miningPubMed
Retraction notice to "Identification of prevention marker associated with DNA replication in ovarian cancer: Expression of MCM2 protein and bioinformatics analysis" [Int. J. Biol. Macromol. 279 (2024) 135079].
Int J Biol Macromol202642586849PubTator, text miningPubMed

1 to 10 of 3,775

See all 3,775 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4171

GET https://conductscience.org/api/genes/v1/4171/patents?page=2