Gene · 4171
MCM2: minichromosome maintenance complex component 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MCM2: minichromosome maintenance complex component 2. Genes, record 4171. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4171
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49736 | DNA replication licensing factor MCM2 | 904 | 39 | Ensembl, GeneID, HGNC |
Source UniProt
Patents62
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2429 | P49736 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2013 | P49736 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4587 | P49736 | Espacenet |
| WO 2025163163 A1 | 2025-08-07 | 1 | P49736 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2013 | P49736 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2429 | P49736 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4587 | P49736 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7007 | P49736 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 14 | P49736 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 51674 | P49736 | Espacenet |
1 to 10 of 62
See all 62 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,980
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MCM2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 22 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 21 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 15 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 10 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 9 | 2025 |
| R01GM045436 | Initiation of DNA Replication at Cell Origins in Yeast | 9 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 8 | 2025 |
| R35GM118015 | Mechanism of Epigenetic Inheritance | 8 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 7 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 7 | 2025 |
1 to 10 of 1,980Source NIH's project files
See all 1,980 nih grantsPapers3,775
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation. | Nat Commun | 2026 | 42733061 | PubTator, text mining | PubMed |
| Brusatol Triggers Cell Cycle Arrest and Apoptosis, Disrupts Sterol Biosynthesis, and Enhances the Anti-Leukemic Activity of Venetoclax in AML Cells. | Cell Biochem Biophys | 2026 | 42711651 | PubTator, text mining | PubMed |
| Suppression of MCM2 reduces cancer stem cells and epithelial-mesenchymal transition-related phenotypes in breast cancer cells. | Korean J Clin Oncol | 2026 | 42687515 | PubTator, text mining | PubMed |
| Evaluation of the clinical and mechanistic role of MCM2 expression in the prediction of meningioma recurrence after radiotherapy. | Neurosurg Focus | 2026 | 42679387 | PubTator, text mining | PubMed |
| MCM2 and p53 Expression Correlate with the Spectrum of Mucinous Ovarian Tumor. | Asian Pac J Cancer Prev | 2026 | 42663211 | PubTator, text mining | PubMed |
| A nomogram model integrating transcriptomics and clinical features for predicting the risk of cervical intraepithelial lesion progression. | Front Oncol | 2026 | 42656450 | PubTator, text mining | PubMed |
| Nat10-mediated ac4C modification sustains macrophage proliferation and mitigates colitis progression via Mcm2 stabilization. | Sci China Life Sci | 2026 | 42645676 | PubTator, text mining | PubMed |
| A complex mutational signature generated by cytarabine resistance. | NAR Cancer | 2026 | 42630438 | PubTator, text mining | PubMed |
| Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data. | iScience | 2026 | 42620746 | PubTator, text mining | PubMed |
Retraction notice to "Identification of prevention marker associated with DNA replication in ovarian cancer: Expression of MCM2 protein and bioinformatics analysis" [Int. J. Biol. Macromol. 279 (2024) 135079]. | Int J Biol Macromol | 2026 | 42586849 | PubTator, text mining | PubMed |
1 to 10 of 3,775
See all 3,775 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4171
GET https://conductscience.org/api/genes/v1/4171/patents?page=2