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Gene · 4173

MCM4: minichromosome maintenance complex component 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MCM4: minichromosome maintenance complex component 4. Genes, record 4173. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4173

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Gene

Symbol
MCM4
HGNC
Name
minichromosome maintenance complex component 4
HGNC
NCBI Gene ID
4173
NCBI Gene
HGNC ID
HGNC:6947
HGNC
Ensembl
ENSG00000104738
NCBI Gene
Aliases
CDC21, CDC54, IMD54, MGC33310, NKCD, NKGCD, P1-CDC21, P1-Cdc21, hCdc21
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P33991DNA replication licensing factor MCM486328Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192013P33991Espacenet
EP 4641202 A22025-10-294531P33991Espacenet
WO 2025163163 A12025-08-073P33991Espacenet
JP 2025517970 A2025-06-122013P33991Espacenet
KR 1020250017231 A2025-02-044531P33991Espacenet
JP 2024123008 A2024-09-107015P33991Espacenet
JP 2024123008 A2024-09-107017P33991Espacenet
US 11446398 B22022-09-2051689P33991Espacenet
US 11446398 B22022-09-2051693P33991Espacenet
JP 2022092366 A2022-06-22631P33991Espacenet

1 to 10 of 61

See all 61 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,344

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMCM4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant182025
R01GM045436Initiation of DNA Replication at Cell Origins in Yeast102025
P30CA014051Cancer Center Support (Core) Grant82025
P30CA016672Cancer Center Support Grant82025
P01CA013106Targeting Transcription and Splicing in Cancer72025
P30CA016056Roswell Park Cancer Center Support Grant72025
P30CA045508CSHL Cancer Center Support Grant62025
R01AI120989Genetic, Immunologic and Mechanistic Basis of Human NK Cell Deficiency62025
R01GM081648Single-molecule visualization of transcription regulation mechanisms52025
R35GM118109Mechanisms linking replication stress to genome instability in fission yeast52025

1 to 10 of 1,344Source NIH's project files

See all 1,344 nih grants

Papers2,283

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation.Nat Commun202642733061PubTator, text miningPubMed
EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy.PLoS One202642691050PubTator, text miningPubMed
Clinical features of hereditary adrenocortical unresponsiveness to adrenocorticotropin (HAUA) in Japan: from a nationwide questionnaire based survey.Endocr J202642586722PubTator, text miningPubMed
Familial glucocorticoid deficiency due to a novel TXNRD2 variant: expanding the spectrum of a rare genetic cause.Front Endocrinol (Lausanne)202642290847PubTator, text miningPubMed
MYC_V1-Related Genes Affect Gastric Cancer Proliferation by Regulating Energy Metabolism and Analysis of Therapeutic Targets.Int J Mol Sci202642278393PubTator, text miningPubMed
The CDK4/6 inhibitor dalpiciclib augments the antitumor efficacy of enzalutamide in preclinical models of castration-resistant prostate cancer through inhibition of MCM4-mediated DNA replication.Cell Death Dis202642248826PubTator, text miningPubMed
Integrative bioinformatics and experimental validation reveal quercetin as a potential multi-target therapeutic agent in hepatocellular carcinoma.Cytotechnology202642145839PubTator, text miningPubMed
Identification of a Prognostic Gene Signature for Chemoresistance Prediction in Lung Adenocarcinoma by Screening Mitochondrial Metabolism Gene Sets.Int J Mol Sci202641977253PubTator, text miningPubMed
Expression of MCM2, MCM4, and MCM10 in hepatocellular carcinoma based on bioinformatic analyses and their predictive value for postoperative recurrence: An initial model development study.Surg Oncol202641921256PubTator, text miningPubMed
Non-invasive host transcriptome and HPV oncogene expression map the molecular landscape of HPV-driven cervical lesions.PLoS One202641855211PubTator, text miningPubMed

1 to 10 of 2,283

See all 2,283 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4173

GET https://conductscience.org/api/genes/v1/4173/patents?page=2