Gene · 4173
MCM4: minichromosome maintenance complex component 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MCM4: minichromosome maintenance complex component 4. Genes, record 4173. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4173
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P33991 | DNA replication licensing factor MCM4 | 863 | 28 | Ensembl, GeneID, HGNC |
Source UniProt
Patents61
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2013 | P33991 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4531 | P33991 | Espacenet |
| WO 2025163163 A1 | 2025-08-07 | 3 | P33991 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2013 | P33991 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4531 | P33991 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7015 | P33991 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7017 | P33991 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 51689 | P33991 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 51693 | P33991 | Espacenet |
| JP 2022092366 A | 2022-06-22 | 631 | P33991 | Espacenet |
1 to 10 of 61
See all 61 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,344
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MCM4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 18 | 2025 |
| R01GM045436 | Initiation of DNA Replication at Cell Origins in Yeast | 10 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 7 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 7 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 6 | 2025 |
| R01AI120989 | Genetic, Immunologic and Mechanistic Basis of Human NK Cell Deficiency | 6 | 2025 |
| R01GM081648 | Single-molecule visualization of transcription regulation mechanisms | 5 | 2025 |
| R35GM118109 | Mechanisms linking replication stress to genome instability in fission yeast | 5 | 2025 |
1 to 10 of 1,344Source NIH's project files
See all 1,344 nih grantsPapers2,283
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation. | Nat Commun | 2026 | 42733061 | PubTator, text mining | PubMed |
| EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy. | PLoS One | 2026 | 42691050 | PubTator, text mining | PubMed |
| Clinical features of hereditary adrenocortical unresponsiveness to adrenocorticotropin (HAUA) in Japan: from a nationwide questionnaire based survey. | Endocr J | 2026 | 42586722 | PubTator, text mining | PubMed |
| Familial glucocorticoid deficiency due to a novel TXNRD2 variant: expanding the spectrum of a rare genetic cause. | Front Endocrinol (Lausanne) | 2026 | 42290847 | PubTator, text mining | PubMed |
| MYC_V1-Related Genes Affect Gastric Cancer Proliferation by Regulating Energy Metabolism and Analysis of Therapeutic Targets. | Int J Mol Sci | 2026 | 42278393 | PubTator, text mining | PubMed |
| The CDK4/6 inhibitor dalpiciclib augments the antitumor efficacy of enzalutamide in preclinical models of castration-resistant prostate cancer through inhibition of MCM4-mediated DNA replication. | Cell Death Dis | 2026 | 42248826 | PubTator, text mining | PubMed |
| Integrative bioinformatics and experimental validation reveal quercetin as a potential multi-target therapeutic agent in hepatocellular carcinoma. | Cytotechnology | 2026 | 42145839 | PubTator, text mining | PubMed |
| Identification of a Prognostic Gene Signature for Chemoresistance Prediction in Lung Adenocarcinoma by Screening Mitochondrial Metabolism Gene Sets. | Int J Mol Sci | 2026 | 41977253 | PubTator, text mining | PubMed |
| Expression of MCM2, MCM4, and MCM10 in hepatocellular carcinoma based on bioinformatic analyses and their predictive value for postoperative recurrence: An initial model development study. | Surg Oncol | 2026 | 41921256 | PubTator, text mining | PubMed |
| Non-invasive host transcriptome and HPV oncogene expression map the molecular landscape of HPV-driven cervical lesions. | PLoS One | 2026 | 41855211 | PubTator, text mining | PubMed |
1 to 10 of 2,283
See all 2,283 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4173
GET https://conductscience.org/api/genes/v1/4173/patents?page=2