Gene · 4174
MCM5: minichromosome maintenance complex component 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MCM5: minichromosome maintenance complex component 5. Genes, record 4174. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4174
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P33992 | DNA replication licensing factor MCM5 | 734 | 27 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2025163163 A1 | 2025-08-07 | 4 | P33992 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7018 | P33992 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1523 | P33992 | Espacenet |
| EP 4215917 A1 | 2023-07-26 | 35 | P33992 | Espacenet |
| US 11519916 B2 | 2022-12-06 | 1 | P33992 | Espacenet |
| JP 2022546121 A | 2022-11-02 | 36 | P33992 | Espacenet |
| JP 2022165963 A | 2022-11-01 | 35 | P33992 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 51696 | P33992 | Espacenet |
| US 11391744 B2 | 2022-07-19 | 35 | P33992 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 154667 | P33992 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,310
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MCM5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 15 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 7 | 2025 |
| R01GM045436 | Initiation of DNA Replication at Cell Origins in Yeast | 7 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 5 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 5 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| R01GM081648 | Single-molecule visualization of transcription regulation mechanisms | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,310Source NIH's project files
See all 1,310 nih grantsPapers2,000
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation. | Nat Commun | 2026 | 42733061 | PubTator, text mining | PubMed |
| A helicase-fused Cas9 improves large-size fragment knockin. | Mol Ther | 2026 | 42528134 | PubTator, text mining | PubMed |
| Retraction: MCM5 aggravates the HDAC1-mediated malignant progression of lung cancer. | Front Cell Dev Biol | 2026 | 42416115 | PubTator, text mining | PubMed |
| Targeting WNK1 suppresses acute myeloid leukemia progression and enhances sensitivity to venetoclax. | Front Oncol | 2026 | 42326325 | PubTator, text mining | PubMed |
| Exploratory transcriptomic and network-based analysis of methylmercury exposure in human neuronal developmental models using GEO datasets and toxicogenomic resources. | Neurotoxicology | 2026 | 42263869 | PubTator, text mining | PubMed |
| Distinct roles of MCM2-7 subunits in replication licensing in human cells. | Nat Commun | 2026 | 42151158 | PubTator, text mining | PubMed |
| RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition. | Cell Death Dis | 2026 | 41888518 | PubTator, text mining | PubMed |
| Integrative analysis of lysosome-dependent cell death related molecular subtypes and prognosis prediction in papillary thyroid carcinoma. | J Cancer | 2026 | 41869448 | PubTator, text mining | PubMed |
| Non-invasive host transcriptome and HPV oncogene expression map the molecular landscape of HPV-driven cervical lesions. | PLoS One | 2026 | 41855211 | PubTator, text mining | PubMed |
| WDHD1 promotes hepatocellular carcinoma progression by affecting the cell cycle and immune evasion. | Transl Oncol | 2026 | 41850053 | PubTator, text mining | PubMed |
1 to 10 of 2,000
See all 2,000 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4174
GET https://conductscience.org/api/genes/v1/4174/patents?page=2