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Gene · 4174

MCM5: minichromosome maintenance complex component 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MCM5: minichromosome maintenance complex component 5. Genes, record 4174. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4174

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Gene

Symbol
MCM5
HGNC
Name
minichromosome maintenance complex component 5
HGNC
NCBI Gene ID
4174
NCBI Gene
HGNC ID
HGNC:6948
HGNC
Ensembl
ENSG00000100297
NCBI Gene
Aliases
CDC46, MGORS8, P1-CDC46
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P33992DNA replication licensing factor MCM573427Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025163163 A12025-08-074P33992Espacenet
JP 2024123008 A2024-09-107018P33992Espacenet
US 11860162 B22024-01-021523P33992Espacenet
EP 4215917 A12023-07-2635P33992Espacenet
US 11519916 B22022-12-061P33992Espacenet
JP 2022546121 A2022-11-0236P33992Espacenet
JP 2022165963 A2022-11-0135P33992Espacenet
US 11446398 B22022-09-2051696P33992Espacenet
US 11391744 B22022-07-1935P33992Espacenet
JP 2022524081 A2022-04-27154667P33992Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,310

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMCM5 papersNewest fiscal year
P30CA008748Cancer Center Support Grant152025
P30CA016672Cancer Center Support Grant102025
P30CA014051Cancer Center Support (Core) Grant72025
R01GM045436Initiation of DNA Replication at Cell Origins in Yeast72025
P01CA013106Targeting Transcription and Splicing in Cancer52025
P30CA046934University of Colorado Cancer Center Support Grant52025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
R01GM081648Single-molecule visualization of transcription regulation mechanisms52025
P30CA006973Regional Oncology Research Center42025
P30CA016056Roswell Park Cancer Center Support Grant42025

1 to 10 of 1,310Source NIH's project files

See all 1,310 nih grants

Papers2,000

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation.Nat Commun202642733061PubTator, text miningPubMed
A helicase-fused Cas9 improves large-size fragment knockin.Mol Ther202642528134PubTator, text miningPubMed
Retraction: MCM5 aggravates the HDAC1-mediated malignant progression of lung cancer.Front Cell Dev Biol202642416115PubTator, text miningPubMed
Targeting WNK1 suppresses acute myeloid leukemia progression and enhances sensitivity to venetoclax.Front Oncol202642326325PubTator, text miningPubMed
Exploratory transcriptomic and network-based analysis of methylmercury exposure in human neuronal developmental models using GEO datasets and toxicogenomic resources.Neurotoxicology202642263869PubTator, text miningPubMed
Distinct roles of MCM2-7 subunits in replication licensing in human cells.Nat Commun202642151158PubTator, text miningPubMed
RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition.Cell Death Dis202641888518PubTator, text miningPubMed
Integrative analysis of lysosome-dependent cell death related molecular subtypes and prognosis prediction in papillary thyroid carcinoma.J Cancer202641869448PubTator, text miningPubMed
Non-invasive host transcriptome and HPV oncogene expression map the molecular landscape of HPV-driven cervical lesions.PLoS One202641855211PubTator, text miningPubMed
WDHD1 promotes hepatocellular carcinoma progression by affecting the cell cycle and immune evasion.Transl Oncol202641850053PubTator, text miningPubMed

1 to 10 of 2,000

See all 2,000 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4174

GET https://conductscience.org/api/genes/v1/4174/patents?page=2