Gene · 4191
MDH2: malate dehydrogenase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MDH2: malate dehydrogenase 2. Genes, record 4191. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4191
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P40926 | Malate dehydrogenase, mitochondrial | 338 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents51
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 52468 | P40926 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5702 | P40926 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5702 | P40926 | Espacenet |
| JP 2024507735 A | 2024-02-21 | 203 | P40926 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 688 | P40926 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 48874 | P40926 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 151845 | P40926 | Espacenet |
| JP 2021534740 A | 2021-12-16 | 84 | P40926 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6691 | P40926 | Espacenet |
| EP 3837353 A1 | 2021-06-23 | 84 | P40926 | Espacenet |
1 to 10 of 51
See all 51 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,254
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MDH2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P20GM121327 | University of Kentucky Center for Cancer Metabolism | 4 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 4 | 2025 |
| R35GM118035 | Metalloenzymes and metal homeostasis | 4 | 2025 |
| I01BX002930 | HDAC7-driven metabolic remodeling in renal tumor progression | 3 | 2025 |
| P30AG028716 | Duke Claude D. Pepper Older Americans Independence Center | 3 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 3 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,254Source NIH's project files
See all 1,254 nih grantsPapers2,409
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Selective methane-to-methanol conversion in a biochar-mediated photocatalytic biohybrid system. | Bioresour Technol | 2026 | 42744025 | PubTator, text mining | PubMed |
| Gut single-microbe landscape in patients with major depressive disorder and bipolar disorder. | Mol Psychiatry | 2026 | 42736349 | PubTator, text mining | PubMed |
| Pyrolusite-mediated denitrifying anaerobic methane oxidation for simultaneous enhancement of nitrogen removal and greenhouse gas mitigation in wetlands. | Bioresour Technol | 2026 | 42727830 | PubTator, text mining | PubMed |
| QM/MM Reveals Coordination Shift behind Early Lanthanide Preference in Methanol Dehydrogenase XoxF. | J Phys Chem B | 2026 | 42720365 | PubTator, text mining | PubMed |
| Dynamics of Citrate Synthase and Malate Dehydrogenase Gene Expression, Enzymatic Activity, and Physicochemical Changes During Postharvest Storage of Soursop (Annona muricata L.) GUANAY-1 Fruit. | Int J Mol Sci | 2026 | 42653179 | PubTator, text mining | PubMed |
| Molecular clusters and precision medicine in pheochromocytomas and paragangliomas. | Endocr Relat Cancer | 2026 | 42626933 | PubTator, text mining | PubMed |
| Purine Metabolism-Related Pathogenic Genes in Trigeminal Neuralgia: A Multiomics Mendelian Randomization Study. | Pain Res Manag | 2026 | 42563458 | PubTator, text mining | PubMed |
| Iron-respiring bacteria mediate regulatory mechanisms and pathways of electron donors and acceptors in carbon and nitrogen cycles. | Appl Environ Microbiol | 2026 | 42484354 | PubTator, text mining | PubMed |
| Integrated proteomics and machine learning for identifying candidate serum biomarkers in acute myocardial infarction-complicated cardiogenic shock: a prospective exploratory study. | Clin Proteomics | 2026 | 42477545 | PubTator, text mining | PubMed |
| Spatial transcriptomics reveals the molecular dynamics of follicular development in the yak ovary under high-altitude hypoxia. | Theriogenology | 2026 | 42468501 | PubTator, text mining | PubMed |
1 to 10 of 2,409
See all 2,409 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4191
GET https://conductscience.org/api/genes/v1/4191/patents?page=2