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Gene · 4191

MDH2: malate dehydrogenase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MDH2: malate dehydrogenase 2. Genes, record 4191. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4191

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Gene

Symbol
MDH2
HGNC
Name
malate dehydrogenase 2
HGNC
NCBI Gene ID
4191
NCBI Gene
HGNC ID
HGNC:6971
HGNC
Ensembl
ENSG00000146701
NCBI Gene
Aliases
DEE51, EIEE51, M-MDH, MDH, MGC:3559, MOR1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P40926Malate dehydrogenase, mitochondrial3387Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452468P40926Espacenet
EP 4650780 A22025-11-195702P40926Espacenet
JP 2025517970 A2025-06-125702P40926Espacenet
JP 2024507735 A2024-02-21203P40926Espacenet
JP 2022141755 A2022-09-29688P40926Espacenet
US 11446398 B22022-09-2048874P40926Espacenet
JP 2022524081 A2022-04-27151845P40926Espacenet
JP 2021534740 A2021-12-1684P40926Espacenet
US 11078247 B22021-08-036691P40926Espacenet
EP 3837353 A12021-06-2384P40926Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,254

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMDH2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
P20GM121327University of Kentucky Center for Cancer Metabolism42025
P30CA054174Mays Cancer Center at UT Health SA42025
R35GM118035Metalloenzymes and metal homeostasis42025
I01BX002930HDAC7-driven metabolic remodeling in renal tumor progression32025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center32025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA013148Comprehensive Cancer Center Support Grant32025

1 to 10 of 1,254Source NIH's project files

See all 1,254 nih grants

Papers2,409

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Selective methane-to-methanol conversion in a biochar-mediated photocatalytic biohybrid system.Bioresour Technol202642744025PubTator, text miningPubMed
Gut single-microbe landscape in patients with major depressive disorder and bipolar disorder.Mol Psychiatry202642736349PubTator, text miningPubMed
Pyrolusite-mediated denitrifying anaerobic methane oxidation for simultaneous enhancement of nitrogen removal and greenhouse gas mitigation in wetlands.Bioresour Technol202642727830PubTator, text miningPubMed
QM/MM Reveals Coordination Shift behind Early Lanthanide Preference in Methanol Dehydrogenase XoxF.J Phys Chem B202642720365PubTator, text miningPubMed
Dynamics of Citrate Synthase and Malate Dehydrogenase Gene Expression, Enzymatic Activity, and Physicochemical Changes During Postharvest Storage of Soursop (Annona muricata L.) GUANAY-1 Fruit.Int J Mol Sci202642653179PubTator, text miningPubMed
Molecular clusters and precision medicine in pheochromocytomas and paragangliomas.Endocr Relat Cancer202642626933PubTator, text miningPubMed
Purine Metabolism-Related Pathogenic Genes in Trigeminal Neuralgia: A Multiomics Mendelian Randomization Study.Pain Res Manag202642563458PubTator, text miningPubMed
Iron-respiring bacteria mediate regulatory mechanisms and pathways of electron donors and acceptors in carbon and nitrogen cycles.Appl Environ Microbiol202642484354PubTator, text miningPubMed
Integrated proteomics and machine learning for identifying candidate serum biomarkers in acute myocardial infarction-complicated cardiogenic shock: a prospective exploratory study.Clin Proteomics202642477545PubTator, text miningPubMed
Spatial transcriptomics reveals the molecular dynamics of follicular development in the yak ovary under high-altitude hypoxia.Theriogenology202642468501PubTator, text miningPubMed

1 to 10 of 2,409

See all 2,409 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4191

GET https://conductscience.org/api/genes/v1/4191/patents?page=2