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Gene · 4192

MDK: midkine

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MDK: midkine. Genes, record 4192. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4192

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Gene

Symbol
MDK
HGNC
Name
midkine
HGNC
NCBI Gene ID
4192
NCBI Gene
HGNC ID
HGNC:6972
HGNC
Ensembl
ENSG00000110492
NCBI Gene
Aliases
ARAP, FLJ27379, MK, NEGF2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21741Midkine1432Ensembl, GeneID, HGNC

Source UniProt

Patents198

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197711P21741Espacenet
JP 2025147176 A2025-10-068494P21741Espacenet
JP 2025147176 A2025-10-068495P21741Espacenet
JP 2025147176 A2025-10-068496P21741Espacenet
JP 2025147176 A2025-10-068497P21741Espacenet
JP 2025147176 A2025-10-068498P21741Espacenet
JP 2025529142 A2025-09-046997P21741Espacenet
JP 2025526646 A2025-08-1575P21741Espacenet
US 12371689 B22025-07-296997P21741Espacenet
EP 4568693 A12025-06-1875P21741Espacenet

1 to 10 of 198

See all 198 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,397

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMDK papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30EY007003University of Michigan Vision Research Center72025
P30AG066511Goizueta Alzheimer's Disease Research Center62025
P30CA021765Cancer Center Support Grant (CCSG)52025
ZIAHD000640Regulation Of Childhood Growth52025
P30AG072980Arizona Alzheimer's Disease Research Center42025
P30CA016672Cancer Center Support Grant42025
U01AA0209124/11 Neuroimmune and extracellular matrix interactions in alcohol consumption42025
ZIABC007365Regulation of ADP-ribosylation factor42025
P30AG072975Rush Alzheimer's Disease Research Center32025

1 to 10 of 1,397Source NIH's project files

See all 1,397 nih grants

Papers2,993

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Glioma Pathogenesis and Treatment Modality: Novel Insights From Midkine Research.Front Biosci (Landmark Ed)202642811999PubTator, text miningPubMed
Maternal cardiovascular, endothelial and inflammatory biomarker dysregulation in twin-twin transfusion syndrome: insights into shared mechanisms with pre-eclampsia.Placenta202642801806PubTator, text miningPubMed
Single-cell and bulk transcriptomic analyses define an IFI27-centered interferon-response epithelial state in bladder cancer and its transcriptional response to irradiation.Front Cell Dev Biol202642798643PubTator, text miningPubMed
Low Serum LDL-C Is Associated with Poorer Overall Survival and Lipid-Related Molecular Features in Colorectal Cancer.Biomedicines202642792654PubTator, text miningPubMed
Spatial Analysis Dissects the Microenvironmental Architecture of Local Recurrence after Breast-Conserving Surgery.Cancer Res202642788441PubTator, text miningPubMed
Micheliolide and ACT001 as Covalent Modulators of Inflammation-Redox-Metabolism Networks in CNS Disorders: An Evidence-Stratified Review of Mechanisms and Translational Challenges.Drug Des Devel Ther202642769100PubTator, text miningPubMed
Transcriptomics-informed systems toxicology prioritizes candidate links between endocrine-disrupting chemicals and chronic kidney disease.Environ Pollut202642759910PubTator, text miningPubMed
Early biomarkers of acute kidney injury after lung transplantation.JHLT Open202642756889PubTator, text miningPubMed
Midkine restrains T-cell mediated anti-tumor immunity by suppressing macrophage M1 polarization in lung adenocarcinoma.Transl Cancer Res202642724375PubTator, text miningPubMed
Multi-omics identification of MBNL2 associated with poor pathological response to neoadjuvant chemoimmunotherapy in lung squamous cell carcinoma.Front Oncol202642688075PubTator, text miningPubMed

1 to 10 of 2,993

See all 2,993 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4192

GET https://conductscience.org/api/genes/v1/4192/patents?page=2