Gene · 4192
MDK: midkine
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MDK: midkine. Genes, record 4192. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4192
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P21741 | Midkine | 143 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents198
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 7711 | P21741 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8494 | P21741 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8495 | P21741 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8496 | P21741 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8497 | P21741 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 8498 | P21741 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6997 | P21741 | Espacenet |
| JP 2025526646 A | 2025-08-15 | 75 | P21741 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6997 | P21741 | Espacenet |
| EP 4568693 A1 | 2025-06-18 | 75 | P21741 | Espacenet |
1 to 10 of 198
See all 198 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,397
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MDK papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| P30EY007003 | University of Michigan Vision Research Center | 7 | 2025 |
| P30AG066511 | Goizueta Alzheimer's Disease Research Center | 6 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| ZIAHD000640 | Regulation Of Childhood Growth | 5 | 2025 |
| P30AG072980 | Arizona Alzheimer's Disease Research Center | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| U01AA020912 | 4/11 Neuroimmune and extracellular matrix interactions in alcohol consumption | 4 | 2025 |
| ZIABC007365 | Regulation of ADP-ribosylation factor | 4 | 2025 |
| P30AG072975 | Rush Alzheimer's Disease Research Center | 3 | 2025 |
1 to 10 of 1,397Source NIH's project files
See all 1,397 nih grantsPapers2,993
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Glioma Pathogenesis and Treatment Modality: Novel Insights From Midkine Research. | Front Biosci (Landmark Ed) | 2026 | 42811999 | PubTator, text mining | PubMed |
| Maternal cardiovascular, endothelial and inflammatory biomarker dysregulation in twin-twin transfusion syndrome: insights into shared mechanisms with pre-eclampsia. | Placenta | 2026 | 42801806 | PubTator, text mining | PubMed |
| Single-cell and bulk transcriptomic analyses define an IFI27-centered interferon-response epithelial state in bladder cancer and its transcriptional response to irradiation. | Front Cell Dev Biol | 2026 | 42798643 | PubTator, text mining | PubMed |
| Low Serum LDL-C Is Associated with Poorer Overall Survival and Lipid-Related Molecular Features in Colorectal Cancer. | Biomedicines | 2026 | 42792654 | PubTator, text mining | PubMed |
| Spatial Analysis Dissects the Microenvironmental Architecture of Local Recurrence after Breast-Conserving Surgery. | Cancer Res | 2026 | 42788441 | PubTator, text mining | PubMed |
| Micheliolide and ACT001 as Covalent Modulators of Inflammation-Redox-Metabolism Networks in CNS Disorders: An Evidence-Stratified Review of Mechanisms and Translational Challenges. | Drug Des Devel Ther | 2026 | 42769100 | PubTator, text mining | PubMed |
| Transcriptomics-informed systems toxicology prioritizes candidate links between endocrine-disrupting chemicals and chronic kidney disease. | Environ Pollut | 2026 | 42759910 | PubTator, text mining | PubMed |
| Early biomarkers of acute kidney injury after lung transplantation. | JHLT Open | 2026 | 42756889 | PubTator, text mining | PubMed |
| Midkine restrains T-cell mediated anti-tumor immunity by suppressing macrophage M1 polarization in lung adenocarcinoma. | Transl Cancer Res | 2026 | 42724375 | PubTator, text mining | PubMed |
| Multi-omics identification of MBNL2 associated with poor pathological response to neoadjuvant chemoimmunotherapy in lung squamous cell carcinoma. | Front Oncol | 2026 | 42688075 | PubTator, text mining | PubMed |
1 to 10 of 2,993
See all 2,993 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4192
GET https://conductscience.org/api/genes/v1/4192/patents?page=2