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MDM2: MDM2 proto-oncogene

1 protein, 79 patents, 4 drugs, 61 trials, 10,702 NIH grants and 32,273 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMDM2HGNC
NameMDM2 proto-oncogeneHGNC
NCBI Gene ID4193NCBI Gene
HGNC IDHGNC:6973HGNC
EnsemblENSG00000135679NCBI Gene
AliasesACTFS, HDM2, HDMX, LSKB, MGC5370, hdm2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q00987E3 ubiquitin-protein ligase Mdm2491147Ensembl, GeneID, HGNCUniProt

Patents 79

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026517823 A2026-06-0221Q00987Espacenet
US 12539325 B22026-02-0361Q00987Espacenet
EP 4650780 A22025-11-1916333Q00987Espacenet
EP 4641201 A22025-10-2920020Q00987Espacenet
JP 2025517969 A2025-06-1220020Q00987Espacenet
JP 2025517970 A2025-06-1216333Q00987Espacenet
JP 2025066140 A2025-04-224Q00987Espacenet
WO 2025061648 A12025-03-271Q00987Espacenet
WO 2024227864 A12024-11-0721Q00987Espacenet
EP 4459287 A12024-11-0621Q00987Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALRIZOMADLINCHEMBL4091801Tumour suppressor p53/oncoprotein Mdm2 inhibitorINHIBITORChEMBL
IDASANUTLINCHEMBL2402737Tumour suppressor p53/oncoprotein Mdm2 inhibitorINHIBITORChEMBL
NAVTEMADLINCHEMBL3125702Tumour suppressor p53/oncoprotein Mdm2 inhibitorINHIBITORChEMBL
SIREMADLINCHEMBL3653256Tumour suppressor p53/oncoprotein Mdm2 inhibitorINHIBITORChEMBL

Trials 61

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06735820ALRIZOMADLINPHASE1/PHASE2ClinicalTrials.gov
NCT06654050ALRIZOMADLINPHASE2ClinicalTrials.gov
NCT06479135NAVTEMADLINPHASE3ClinicalTrials.gov
NCT05952687IDASANUTLINPHASE1ClinicalTrials.gov
NCT05797831NAVTEMADLINPHASE2/PHASE3ClinicalTrials.gov
NCT05705466NAVTEMADLINPHASE1/PHASE2ClinicalTrials.gov
NCT05701306ALRIZOMADLINPHASE1/PHASE2ClinicalTrials.gov
NCT05447663SIREMADLINPHASE1/PHASE22025-01-14ClinicalTrials.gov
NCT05180695SIREMADLINPHASE1/PHASE2ClinicalTrials.gov
NCT05155709SIREMADLINPHASE1ClinicalTrials.gov

NIH grants 10702

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant4072,025NIH's project files
P30CA008748Cancer Center Support Grant2682,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)992,025NIH's project files
P30CA016058Cancer Center Support Grant532,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028472,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant452,025NIH's project files
P30CA006973Regional Oncology Research Center442,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase412,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant412,025NIH's project files
P30CA068485Cancer Center Support Grant392,025NIH's project files

Papers 32273

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822321PubTator, text miningPubMed
42822143PubTator, text miningPubMed
42821135PubTator, text miningPubMed
42818024PubTator, text miningPubMed
42814245PubTator, text miningPubMed
42812828PubTator, text miningPubMed
42812154PubTator, text miningPubMed
42803984PubTator, text miningPubMed
42798448PubTator, text miningPubMed
42793175PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license