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MDM4: MDM4 regulator of p53

1 protein, 25 patents, 0 drugs, 0 trials, 2,750 NIH grants and 4,733 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMDM4HGNC
NameMDM4 regulator of p53HGNC
NCBI Gene ID4194NCBI Gene
HGNC IDHGNC:6974HGNC
EnsemblENSG00000198625NCBI Gene
AliasesBMFS6, HDMX, MDMX, MRP1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15151Protein Mdm449039Ensembl, GeneID, HGNCUniProt

Patents 25

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2025066140 A2025-04-226O15151Espacenet
JP 2024123008 A2024-09-106912O15151Espacenet
JP 2023089245 A2023-06-276O15151Espacenet
US 11446398 B22022-09-2049633O15151Espacenet
US 11407840 B22022-08-096O15151Espacenet
JP 2022524081 A2022-04-27152604O15151Espacenet
WO 2021222243 A22021-11-04104O15151Espacenet
JP 2020528936 A2020-10-0114O15151Espacenet
US 10501513 B22019-12-106912O15151Espacenet
US 9890429 B22018-02-1312O15151Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2750

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant952,025NIH's project files
P30CA008748Cancer Center Support Grant442,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)252,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant232,025NIH's project files
R01CA047296A Pathway of Tumor Suppression172,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant162,025NIH's project files
P30CA016058Cancer Center Support Grant132,025NIH's project files
P30CA006973Regional Oncology Research Center122,025NIH's project files
R01CA141244Allosteric Regulation of MDMX by Protein Disorder122,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE112,025NIH's project files

Papers 4733

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822321PubTator, text miningPubMed
42802834PubTator, text miningPubMed
42738851PubTator, text miningPubMed
42697596PubTator, text miningPubMed
42660122PubTator, text miningPubMed
42631482PubTator, text miningPubMed
42614981PubTator, text miningPubMed
42591639PubTator, text miningPubMed
42575349PubTator, text miningPubMed
42560626PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license