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ME1: malic enzyme 1

1 protein, 55 patents, 0 drugs, 0 trials, 1,865 NIH grants and 9,867 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolME1HGNC
Namemalic enzyme 1HGNC
NCBI Gene ID4199NCBI Gene
HGNC IDHGNC:6983HGNC
EnsemblENSG00000065833NCBI Gene
AliasesHUMNDME, MESNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P48163NADP-dependent malic enzyme5724Ensembl, GeneID, HGNCUniProt

Patents 55

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452475P48163Espacenet
EP 4650780 A22025-11-198658P48163Espacenet
EP 4641201 A22025-10-298840P48163Espacenet
EP 4641202 A22025-10-295466P48163Espacenet
EP 4611773 A12025-09-109P48163Espacenet
JP 2025517969 A2025-06-128840P48163Espacenet
JP 2025517970 A2025-06-128658P48163Espacenet
JP 2025081326 A2025-05-2746P48163Espacenet
KR 1020250017231 A2025-02-045466P48163Espacenet
JP 2022147356 A2022-10-06296P48163Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 1865

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant72,025NIH's project files
P01CA117969Genetics and Biology of Pancreatic Ductal Adenocarcinoma62,025NIH's project files
P30CA008748Cancer Center Support Grant62,025NIH's project files
P30CA072720Cancer Center Support Grant62,025NIH's project files
R01CA163591Tumor cell metabolism in action62,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant52,025NIH's project files
R37CA237421Intratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic Cancer52,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center42,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes32,025NIH's project files

Papers 9867

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42772720PubTator, text miningPubMed
42728262PubTator, text miningPubMed
42719331PubTator, text miningPubMed
42694441PubTator, text miningPubMed
42653179PubTator, text miningPubMed
42591310PubTator, text miningPubMed
42580490PubTator, text miningPubMed
42369572PubTator, text miningPubMed
42358703PubTator, text miningPubMed
42353036PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license