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Gene · 4200

ME2: malic enzyme 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ME2: malic enzyme 2. Genes, record 4200. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4200

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Gene

Symbol
ME2
HGNC
Name
malic enzyme 2
HGNC
NCBI Gene ID
4200
NCBI Gene
HGNC ID
HGNC:6984
HGNC
Ensembl
ENSG00000082212
NCBI Gene
Aliases
ODS1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23368NAD-dependent malic enzyme, mitochondrial58418Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452479P23368Espacenet
EP 4641201 A22025-10-294947P23368Espacenet
JP 2025517969 A2025-06-124947P23368Espacenet
US 11446398 B22022-09-2048910P23368Espacenet
JP 2022524081 A2022-04-27151881P23368Espacenet
JP 2019054813 A2019-04-11232914P23368Espacenet
JP 2017121241 A2017-07-13232914P23368Espacenet
JP 2015516143 A2015-06-08232914P23368Espacenet
US 8541550 B22013-09-2437P23368Espacenet
US 8507277 B22013-08-1337P23368Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,820

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleME2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30CA016672Cancer Center Support Grant92025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant72025
R01CA163591Tumor cell metabolism in action52025
T32GM008315Mechanisms of Trauma-Induced Coagulopathy52025
P20GM121327University of Kentucky Center for Cancer Metabolism42025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30ES013508Center of Excellence in Environmental Toxicology42025
P40OD010440Caenorhabditis Genetics Center42025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism42025

1 to 10 of 1,820Source NIH's project files

See all 1,820 nih grants

Papers3,297

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Author Correction: Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.Nature202642754698PubTator, text miningPubMed
Systems pharmacology reveals type I interferon and myeloid-like B cell reprogramming as candidate druggable axes in antiphospholipid syndrome.PLoS One202642647509PubTator, text miningPubMed
Resolving challenges in detection and quantification of D-2-hydroxyglutarate and L-2-hydroxyglutarate via LC/MS.Methods202642632435PubTator, text miningPubMed
Disakisperma species (Poaceae): C4 halophytes with ion excretion via salt glands.Planta202642599521PubTator, text miningPubMed
A cryptic allosteric pocket shapes isoform-selective inhibition of human malic enzymes.Protein Sci202642581399PubTator, text miningPubMed
Malate synthesis in the chloroplasts of C3 plants.Curr Opin Plant Biol202642475967PubTator, text miningPubMed
Adaptations to intertidal life: divergence of energy metabolism enzyme pathways in marine polychaetes.Adv Physiol Educ202642422988PubTator, text miningPubMed
Six Dehydrogenase Gatekeepers of Carbohydrate Metabolism: Metabolic Integration in Health and Disease.Front Biosci (Landmark Ed)202642411477PubTator, text miningPubMed
Building Hovenia dulcis pseudofruit quality from proteomic and metabolomic perspectives.Food Chem (Oxf)202642328325PubTator, text miningPubMed
Cross-Platform Assessment of Sub-50 nm Nanopipette Emitters for Native Electrospray Ionization Mass Spectrometry.bioRxiv202642239418PubTator, text miningPubMed

1 to 10 of 3,297

See all 3,297 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4200

GET https://conductscience.org/api/genes/v1/4200/patents?page=2