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MECP2: methyl-CpG binding protein 2

1 protein, 120 patents, 0 drugs, 0 trials, 5,416 NIH grants and 9,502 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMECP2HGNC
Namemethyl-CpG binding protein 2HGNC
NCBI Gene ID4204NCBI Gene
HGNC IDHGNC:6990HGNC
EnsemblENSG00000169057NCBI Gene
AliasesAUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTTNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P51608Methyl-CpG-binding protein 248611Ensembl, GeneID, HGNCUniProt

Patents 120

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4828973 A22026-10-2847P51608Espacenet
EP 4805378 A12026-09-16612P51608Espacenet
EP 4791408 A12026-08-19364P51608Espacenet
EP 4791447 A22026-08-19923P51608Espacenet
JP 2026523341 A2026-07-141063P51608Espacenet
EP 4771137 A12026-07-08630P51608Espacenet
EP 4771157 A12026-07-08630P51608Espacenet
US 12649003 B22026-06-091063P51608Espacenet
JP 2026513692 A2026-04-30322P51608Espacenet
JP 2026511500 A2026-04-1428P51608Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5416

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01NS057819MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROME542,025NIH's project files
P50HD103537Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt322,025NIH's project files
P50HD103555Baylor College of Medicine Intellectual and Developmental Disabilities Research Center182,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
R01NS081054Understanding the Pathogenic Mechanisms of Rett Syndrome132,025NIH's project files
R01MH085802Early developmental mechanisms of Rett Syndrome122,025NIH's project files
P30CA093373Cancer Center Support Grant P30102,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis102,025NIH's project files
R01MH101221Rare Mutations and Autism Spectrum Disorders102,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant92,025NIH's project files

Papers 9502

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818733PubTator, text miningPubMed
42811632PubTator, text miningPubMed
42802491PubTator, text miningPubMed
42770329PubTator, text miningPubMed
42720792PubTator, text miningPubMed
42698224PubTator, text miningPubMed
42679808PubTator, text miningPubMed
42646356PubTator, text miningPubMed
42645536PubTator, text miningPubMed
42632612PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license