Gene · 4210
MEFV: MEFV innate immunity regulator, pyrin
11 sourcesgene-search-2026-11-11-0.1.0
Cite this record
ConductScience Library. MEFV: MEFV innate immunity regulator, pyrin. Genes, record 4210. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/4210
On this page
Gene
Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15553 | Pyrin | 781 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026190490 A1 | 2026-09-17 | 1 | O15553 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52969 | O15553 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 51 | O15553 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 316 | O15553 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 51 | O15553 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 316 | O15553 | Espacenet |
| US 12285470 B2 | 2025-04-29 | 7 | O15553 | Espacenet |
| JP 2024161501 A | 2024-11-19 | 40 | O15553 | Espacenet |
| KR 1020240108531 A | 2024-07-09 | 40 | O15553 | Espacenet |
| JP 2024522216 A | 2024-06-11 | 116 | O15553 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,417
NIH projects whose papers are about the gene, through NIH's grant-paper links.
| Project | Title | Its papers about the gene | Newest fiscal year |
|---|---|---|---|
| R01AI124346 | Innate immune signaling and stress response | 22 | 2025 |
| R37AI101935 | Inflammatory Caspases in Innate Immunity and Inflammation | 21 | 2025 |
| ZIAHG200372 | Genetics, Pathophysiology, and Treatment of Autoinflammatory and Autoimmune Diseases | 19 | 2025 |
| ZIDAR041180 | Clinical Support Services for the NIAMS Intramural Research Program | 11 | 2025 |
| R35CA253095 | Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer | 8 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 7 | 2025 |
| R01AI160179 | Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases | 7 | 2025 |
| ZIAAI001220 | Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases | 7 | 2025 |
| R01AI099222 | Regulation of host innate and adaptive immunity by bacterial type III effectors | 6 | 2025 |
| R01AI124491 | NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing | 6 | 2025 |
1 to 10 of 1,417Source NIH's project files
See all 1,417 nih grantsPapers4,381
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| PMID | Found by | Source |
|---|---|---|
| 42821198 | PubTator, text mining | PubMed |
| 42814219 | PubTator, text mining | PubMed |
| 42811258 | PubTator, text mining | PubMed |
| 42811127 | PubTator, text mining | PubMed |
| 42792891 | PubTator, text mining | PubMed |
| 42789246 | PubTator, text mining | PubMed |
| 42788745 | PubTator, text mining | PubMed |
| 42786430 | PubTator, text mining | PubMed |
| 42777195 | PubTator, text mining | PubMed |
| 42776304 | PubTator, text mining | PubMed |
1 to 10 of 4,381
See all 4,381 papersSources 11
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNone stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GeneNone named. Public domain as US government information
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4210
GET https://conductscience.org/api/genes/v1/4210/patents?page=2