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Gene · 4210

MEFV: MEFV innate immunity regulator, pyrin

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. MEFV: MEFV innate immunity regulator, pyrin. Genes, record 4210. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/4210

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
MEFV
HGNC
Name
MEFV innate immunity regulator, pyrin
HGNC
NCBI Gene ID
4210
NCBI Gene
HGNC ID
HGNC:6998
HGNC
Ensembl
ENSG00000103313
NCBI Gene
Aliases
FMF, MEF, PAAND, TRIM20
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15553Pyrin78111Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026190490 A12026-09-171O15553Espacenet
JP 2026004568 A2026-01-1452969O15553Espacenet
EP 4640849 A22025-10-2951O15553Espacenet
EP 4641201 A22025-10-29316O15553Espacenet
JP 2025519096 A2025-06-2451O15553Espacenet
JP 2025517969 A2025-06-12316O15553Espacenet
US 12285470 B22025-04-297O15553Espacenet
JP 2024161501 A2024-11-1940O15553Espacenet
KR 1020240108531 A2024-07-0940O15553Espacenet
JP 2024522216 A2024-06-11116O15553Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,417

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01AI124346Innate immune signaling and stress response222025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation212025
ZIAHG200372Genetics, Pathophysiology, and Treatment of Autoinflammatory and Autoimmune Diseases192025
ZIDAR041180Clinical Support Services for the NIAMS Intramural Research Program112025
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer82025
P30DK034854Integrated Epithelial and Muscosal Biology72025
R01AI160179Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases72025
ZIAAI001220Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases72025
R01AI099222Regulation of host innate and adaptive immunity by bacterial type III effectors62025
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing62025

1 to 10 of 1,417Source NIH's project files

See all 1,417 nih grants

Papers4,381

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821198PubTator, text miningPubMed
42814219PubTator, text miningPubMed
42811258PubTator, text miningPubMed
42811127PubTator, text miningPubMed
42792891PubTator, text miningPubMed
42789246PubTator, text miningPubMed
42788745PubTator, text miningPubMed
42786430PubTator, text miningPubMed
42777195PubTator, text miningPubMed
42776304PubTator, text miningPubMed

1 to 10 of 4,381

See all 4,381 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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