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Gene · 4214

MAP3K1: mitogen-activated protein kinase kinase kinase 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. MAP3K1: mitogen-activated protein kinase kinase kinase 1. Genes, record 4214. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/4214

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
MAP3K1
HGNC
Name
mitogen-activated protein kinase kinase kinase 1
HGNC
NCBI Gene ID
4214
NCBI Gene
HGNC ID
HGNC:6848
HGNC
Ensembl
ENSG00000095015
NCBI Gene
Aliases
MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13233Mitogen-activated protein kinase kinase kinase 11,5121Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911671Q13233Espacenet
EP 4641201 A22025-10-2912304Q13233Espacenet
JP 2025529142 A2025-09-042536Q13233Espacenet
US 12371689 B22025-07-292536Q13233Espacenet
JP 2025517969 A2025-06-1212304Q13233Espacenet
JP 2025517970 A2025-06-1211671Q13233Espacenet
JP 2024121274 A2024-09-065Q13233Espacenet
US 11708396 B22023-07-251785Q13233Espacenet
US 11685953 B22023-06-2714Q13233Espacenet
US 11685953 B22023-06-2719Q13233Espacenet

1 to 10 of 26

See all 26 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
E-6201CHEMBL1097999Mitogen-activated protein kinase kinase kinase 1 inhibitorINHIBITOR

Source ChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05388877E-6201PHASE1ClinicalTrials.gov
NCT03332589E-6201PHASE12022-05-20ClinicalTrials.gov
NCT02418000E-6201PHASE1/PHASE22019-03-05ClinicalTrials.gov
NCT01268527E-6201PHASE22021-06-11ClinicalTrials.gov

NIH grants3,278

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA008748Cancer Center Support Grant502025
P30CA016672Cancer Center Support Grant482025
P50CA116201Mayo Clinic Breast Cancer SPORE312025
P50CA058223SPORE in Breast Cancer232025
P30CA068485Cancer Center Support Grant162025
P30ES010126UNC Center for Environmental Health and Susceptibility142025
ZIACP010126Hormone-Related Cancers132025
P30CA016056Roswell Park Cancer Center Support Grant122025
P30CA016086Cancer Center Support Grant112025
P30CA091842Cancer Center Support Grant102025

1 to 10 of 3,278Source NIH's project files

See all 3,278 nih grants

Papers4,517

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42795000PubTator, text miningPubMed
42735455PubTator, text miningPubMed
42724992PubTator, text miningPubMed
42698337PubTator, text miningPubMed
42663228PubTator, text miningPubMed
42573210PubTator, text miningPubMed
42353095PubTator, text miningPubMed
42134655PubTator, text miningPubMed
42104510PubTator, text miningPubMed
41974248PubTator, text miningPubMed

1 to 10 of 4,517

See all 4,517 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4214

GET https://conductscience.org/api/genes/v1/4214/patents?page=2