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Gene · 4216

MAP3K4: mitogen-activated protein kinase kinase kinase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAP3K4: mitogen-activated protein kinase kinase kinase 4. Genes, record 4216. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4216

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Gene

Symbol
MAP3K4
HGNC
Name
mitogen-activated protein kinase kinase kinase 4
HGNC
NCBI Gene ID
4216
NCBI Gene
HGNC ID
HGNC:6856
HGNC
Ensembl
ENSG00000085511
NCBI Gene
Aliases
KIAA0213, MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y6R4Mitogen-activated protein kinase kinase kinase 41,6080Ensembl, GeneID, HGNC

Source UniProt

Patents8

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453977Q9Y6R4Espacenet
EP 4641201 A22025-10-2911273Q9Y6R4Espacenet
JP 2025517969 A2025-06-1211273Q9Y6R4Espacenet
US 11446398 B22022-09-2052569Q9Y6R4Espacenet
JP 2022524081 A2022-04-27155540Q9Y6R4Espacenet
JP 2019054813 A2019-04-11234412Q9Y6R4Espacenet
JP 2017121241 A2017-07-13234412Q9Y6R4Espacenet
JP 2015516143 A2015-06-08234412Q9Y6R4Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,476

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAP3K4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant122025
P40OD010440Caenorhabditis Genetics Center92025
P30ES006694Southwest Environmental Health Sciences Center62025
P30CA016086Cancer Center Support Grant52025
P30CA016087Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P42ES004940The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation52025
P30CA021765Cancer Center Support Grant (CCSG)42025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement42025
U10CA180899Children's Oncology Group Statistics and Data Center42025

1 to 10 of 1,476Source NIH's project files

See all 1,476 nih grants

Papers2,164

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Insights from GWAS, TWAS, and DEG analysis: CDKN2B-AS1, MAP3K4, and P2RX2-encoded P2X2 receptor identified as potential therapeutic targets for ischemic heart disease in Russian adults and long-living individuals.
Front Cardiovasc Med202642662925PubTator, text miningPubMed
Circular RNAs in cancer: Its biogenesis, functions, relationships with cancer progression, applications in immunotherapy and biomarker potentials.Cancer Immunol Immunother202641915211PubTator, text miningPubMed
MPK3 as a Signalling Hub in Plants: Integrating Plant Growth, Development and Stress Response.Plants (Basel)202641901438PubTator, text miningPubMed
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal Transduct Target Ther202641881983PubTator, text miningPubMed
ERKed by too much signaling: from oncogenic driver to therapeutic vulnerability.Cell Mol Life Sci202641865130PubTator, text miningPubMed
Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review).Int J Oncol202641860028PubTator, text miningPubMed
Bacterial EVs contain small RNAs and transfer RNAs that regulate inflammation in lung infections.Front Immunol202641789105PubTator, text miningPubMed
Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies.Signal Transduct Target Ther202641786685PubTator, text miningPubMed
Targeting the JNK Gatekeepers: Structural Evolution and Medicinal Chemistry of MKK4 and MKK7 Inhibitors.Molecules202641752451PubTator, text miningPubMed
Let-7a and miR-34a Interplay Potent Suppressive Roles in Hepatocellular Carcinoma via Co-Targeting FNDC3B, IGF2 and SOX4.Int J Mol Sci202641751849PubTator, text miningPubMed

1 to 10 of 2,164

See all 2,164 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4216

GET https://conductscience.org/api/genes/v1/4216/grants?page=2