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MAP3K5: mitogen-activated protein kinase kinase kinase 5

1 protein, 54 patents, 1 drug, 9 trials, 2,820 NIH grants and 5,983 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMAP3K5HGNC
Namemitogen-activated protein kinase kinase kinase 5HGNC
NCBI Gene ID4217NCBI Gene
HGNC IDHGNC:6857HGNC
EnsemblENSG00000197442NCBI Gene
AliasesASK1, MAPKKK5, MEKK5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q99683Mitogen-activated protein kinase kinase kinase 51,37427Ensembl, GeneID, HGNCUniProt

Patents 54

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453981Q99683Espacenet
EP 4641201 A22025-10-297643Q99683Espacenet
JP 2025517969 A2025-06-127643Q99683Espacenet
US 11884978 B22024-01-30591Q99683Espacenet
US 11708396 B22023-07-251417Q99683Espacenet
US 11446398 B22022-09-2052574Q99683Espacenet
JP 2022524081 A2022-04-27155545Q99683Espacenet
JP 2022512897 A2022-02-07296Q99683Espacenet
JP 2022502433 A2022-01-11296Q99683Espacenet
JP 2022502435 A2022-01-11296Q99683Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
SELONSERTIBCHEMBL3916717Mitogen-activated protein kinase kinase kinase 5 inhibitorINHIBITORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04026165SELONSERTIBPHASE22022-12-21ClinicalTrials.gov
NCT03449446SELONSERTIBPHASE22020-12-03ClinicalTrials.gov
NCT03053063SELONSERTIBPHASE32020-05-07ClinicalTrials.gov
NCT03053050SELONSERTIBPHASE32020-06-29ClinicalTrials.gov
NCT02854631SELONSERTIBPHASE22019-02-06ClinicalTrials.gov
NCT02781584SELONSERTIBPHASE22022-02-02ClinicalTrials.gov
NCT02466516SELONSERTIBPHASE22019-06-26ClinicalTrials.gov
NCT02234141SELONSERTIBPHASE22019-04-10ClinicalTrials.gov
NCT02177786SELONSERTIBPHASE22019-06-11ClinicalTrials.gov

NIH grants 2820

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01EY011500Structure-function studies of visual arrestin262,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
P30DK120515San Diego Digestive Diseases Research Center92,025NIH's project files
U01DK061734Clinical Research on Nonalcoholic Fatty Liver Disease82,025NIH's project files
P30CA016058Cancer Center Support Grant72,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)72,025NIH's project files
P30CA008748Cancer Center Support Grant62,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis62,025NIH's project files
R01GM086858New Molecular Probes For Protein Kinases62,025NIH's project files
P30AG024832UTMB Claude D. Pepper Older Americans Independence Center52,025NIH's project files

Papers 5983

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42778936PubTator, text miningPubMed
42767444PubTator, text miningPubMed
42746114PubTator, text miningPubMed
42719470PubTator, text miningPubMed
42697978PubTator, text miningPubMed
42696915PubTator, text miningPubMed
42667964PubTator, text miningPubMed
42640247PubTator, text miningPubMed
42617932PubTator, text miningPubMed
42606110PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license