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Gene · 4218

RAB8A: RAB8A, member RAS oncogene family

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAB8A: RAB8A, member RAS oncogene family. Genes, record 4218. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4218

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Gene

Symbol
RAB8A
HGNC
Name
RAB8A, member RAS oncogene family
HGNC
NCBI Gene ID
4218
NCBI Gene
HGNC ID
HGNC:7007
HGNC
Ensembl
ENSG00000167461
NCBI Gene
Aliases
MEL, RAB8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61006Ras-related protein Rab-8A20721Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460768P61006Espacenet
EP 4650780 A22025-11-194031P61006Espacenet
JP 2025517970 A2025-06-124031P61006Espacenet
EP 4487869 A22025-01-08421P61006Espacenet
KR 1020240027895 A2024-03-04609P61006Espacenet
US 11834717 B22023-12-0514P61006Espacenet
US 11661461 B22023-05-30124P61006Espacenet
JP 2023036863 A2023-03-14609P61006Espacenet
US 11446398 B22022-09-2070870P61006Espacenet
JP 2022524081 A2022-04-27173841P61006Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,377

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAB8A papersNewest fiscal year
R01DK048370Small GTP Binding Proteins in Gastrointestinal Mucosa192025
P30DK058404Molecular and Cellular Basis for Digestive Diseases162025
P30CA068485Cancer Center Support Grant122025
P30DK020593Vanderbilt Diabetes Research Center102025
ZIABC011398Regulation of Ciliogenesis and Ciliary-related signaling92025
R01DK064380Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis72025
R01GM060992Intraflagellar Transport Proteins in Mice72025
T32CA106183Surgical Oncology Training Grant72025
ZIAAG000948Leucine rich repeat kinase 2 and dominantly inherited Parkinson disease72025
P30CA036727Buffett Cancer Center Support Grant62025

1 to 10 of 1,377Source NIH's project files

See all 1,377 nih grants

Papers1,989

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
LRRK2: Molecular Mechanisms in Parkinson's Disease.Int J Mol Sci202642737506PubTator, text miningPubMed
Avl9 defines a family of DENN domain GTPase-activating proteins.J Cell Biol202642714338PubTator, text miningPubMed
Autophagic degradation of RAB8A promotes ferroptosis through dysregulation of TFRC-mediated iron uptake.Autophagy202642669120PubTator, text miningPubMed
ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles.J Extracell Vesicles202642667673PubTator, text miningPubMed
Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress.iScience202642630748PubTator, text miningPubMed
Glial control of extracellular α-synuclein propagation in LRRK2 Parkinson's disease.Adv Immunol202642629126PubTator, text miningPubMed
Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.MedComm (2020)202642568782PubTator, text miningPubMed
Characterization of membrane structures regulating primary ciliogenesis by quantitative isotropic ultrastructure imaging.Nat Commun202642288497PubTator, text miningPubMed
An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death.J Cell Sci202642206576PubTator, text miningPubMed
Midbody Remnants as Signaling Centers in Cell Fate Determination and Tumorigenesis.DNA Cell Biol202642077099PubTator, text miningPubMed

1 to 10 of 1,989

See all 1,989 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4218

GET https://conductscience.org/api/genes/v1/4218/patents?page=2