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MEN1: menin 1

1 protein, 59 patents, 4 drugs, 24 trials, 2,129 NIH grants and 5,476 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMEN1HGNC
Namemenin 1HGNC
NCBI Gene ID4221NCBI Gene
HGNC IDHGNC:7010HGNC
EnsemblENSG00000133895NCBI Gene
AliasesMEAI, SCG2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O00255Menin61069Ensembl, GeneID, HGNCUniProt

Patents 59

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194590O00255Espacenet
EP 4641201 A22025-10-294149O00255Espacenet
JP 2025098022 A2025-07-012O00255Espacenet
JP 2025517969 A2025-06-124149O00255Espacenet
JP 2025517970 A2025-06-124590O00255Espacenet
JP 2024123008 A2024-09-107107O00255Espacenet
JP 2024123008 A2024-09-107108O00255Espacenet
JP 2024123008 A2024-09-107113O00255Espacenet
US 11944627 B22024-04-022O00255Espacenet
EP 4219449 A22023-08-022O00255Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
REVUMENIBCHEMBL4650827Menin/Histone-lysine N-methyltransferase MLL inhibitorINHIBITORChEMBL
REVUMENIBCHEMBL4650827Menin inhibitorINHIBITORChEMBL
REVUMENIB CITRATECHEMBL6068395Menin inhibitorINHIBITORChEMBL
REVUMENIB SESQUIFUMARATECHEMBL4650278Menin/Histone-lysine N-methyltransferase MLL inhibitorINHIBITORChEMBL

Trials 24

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605949REVUMENIBPHASE2ClinicalTrials.gov
NCT07563010REVUMENIBPHASE2ClinicalTrials.gov
NCT07498465REVUMENIBPHASE1ClinicalTrials.gov
NCT07356154REVUMENIBPHASE1/PHASE2ClinicalTrials.gov
NCT07283640REVUMENIBPHASE1ClinicalTrials.gov
NCT07211958REVUMENIBPHASE3ClinicalTrials.gov
NCT07052994REVUMENIBPHASE1ClinicalTrials.gov
NCT06652438REVUMENIBPHASE3ClinicalTrials.gov
NCT06575296REVUMENIBPHASE1ClinicalTrials.gov
NCT06313437REVUMENIBPHASE1ClinicalTrials.gov

NIH grants 2129

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant872,025NIH's project files
P30CA016672Cancer Center Support Grant422,025NIH's project files
ZIADK053200Diagnosis, Natural History, Management, tumor biology of Gastrinomas/PETs/Neuroendocrine tumors262,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias232,025NIH's project files
ZIABC011286Therapeutic targets and novel anticancer agents for endocrine cancers192,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028182,025NIH's project files
ZIADK043006Hyperparathyroidism -- Etiology, Diagnosis and Treatment182,025NIH's project files
P30CA006973Regional Oncology Research Center152,025NIH's project files
ZIAHG000029Fanconi Anemia: Genotype-Phenotype Correlations142,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)122,025NIH's project files

Papers 5476

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822599PubTator, text miningPubMed
42807949PubTator, text miningPubMed
42805358PubTator, text miningPubMed
42795012PubTator, text miningPubMed
42794433PubTator, text miningPubMed
42771820PubTator, text miningPubMed
42750903PubTator, text miningPubMed
42738274PubTator, text miningPubMed
42733371PubTator, text miningPubMed
42733002PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license