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MET: MET proto-oncogene, receptor tyrosine kinase

1 protein, 286 patents, 40 drugs, 579 trials, 6,341 NIH grants and 19,560 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMETHGNC
NameMET proto-oncogene, receptor tyrosine kinaseHGNC
NCBI Gene ID4233NCBI Gene
HGNC IDHGNC:7029HGNC
EnsemblENSG00000105976NCBI Gene
AliasesAUTS9, DA11, DFNB97, HGFR, RCCP2, c-MetNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08581Hepatocyte growth factor receptor1,390130Ensembl, GeneID, HGNCUniProt

Patents 286

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026518691 A2026-06-0931P08581Espacenet
US 12636345 B22026-05-2649P08581Espacenet
US 12605473 B22026-04-21146P08581Espacenet
JP 2026510963 A2026-04-1065P08581Espacenet
JP 2026505164 A2026-02-1269P08581Espacenet
WO 2026021476 A12026-01-2969P08581Espacenet
JP 2026502348 A2026-01-222100P08581Espacenet
EP 4680648 A12026-01-2165P08581Espacenet
JP 2026004432 A2026-01-1452P08581Espacenet
US 12514926 B22026-01-0652P08581Espacenet

Drugs 40

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALTIRATINIBCHEMBL3545365Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL
AMG-208CHEMBL496102Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL
AMG-337CHEMBL3785909Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL
AMIVANTAMABCHEMBL4297774Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL
AMUVATINIBCHEMBL2103851Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL
ARRY-300CHEMBL3545359Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL
BAFISONTAMABCHEMBL4594472Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL
BEPERMINOGENE PERPLASMIDCHEMBL2108332Hepatocyte growth factor receptor agonistAGONISTChEMBL
BMS-698769CHEMBL3545299Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL
BMS-777607CHEMBL460702Hepatocyte growth factor receptor inhibitorINHIBITORChEMBL

Trials 579

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07586202AMIVANTAMABPHASE2ClinicalTrials.gov
NCT07560410CRIZOTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07507188AMIVANTAMABPHASE2ClinicalTrials.gov
NCT07469488AMIVANTAMABPHASE4ClinicalTrials.gov
NCT07392658AMIVANTAMABPHASE2ClinicalTrials.gov
NCT07323641TELISOTUZUMAB VEDOTINPHASE2ClinicalTrials.gov
NCT07322783SAVOLITINIBPHASE2ClinicalTrials.gov
NCT07314294BAFISONTAMABPHASE2ClinicalTrials.gov
NCT07293351CABOZANTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07276399AMIVANTAMABPHASE3ClinicalTrials.gov

NIH grants 6341

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2252,025NIH's project files
P30CA008748Cancer Center Support Grant892,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant352,025NIH's project files
P30CA006973Regional Oncology Research Center342,025NIH's project files
P30DK026743UCSF Liver Center332,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant282,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase262,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT262,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support232,025NIH's project files
P30CA016058Cancer Center Support Grant232,025NIH's project files

Papers 19560

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824815PubTator, text miningPubMed
42818257PubTator, text miningPubMed
42815071PubTator, text miningPubMed
42810192PubTator, text miningPubMed
42794437PubTator, text miningPubMed
42793258PubTator, text miningPubMed
42793224PubTator, text miningPubMed
42782114PubTator, text miningPubMed
42780611PubTator, text miningPubMed
42778195PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license