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Gene · 4240

MFGE8: milk fat globule EGF and factor V/VIII domain containing

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MFGE8: milk fat globule EGF and factor V/VIII domain containing. Genes, record 4240. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4240

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Gene

Symbol
MFGE8
HGNC
Name
milk fat globule EGF and factor V/VIII domain containing
HGNC
NCBI Gene ID
4240
NCBI Gene
HGNC ID
HGNC:7036
HGNC
Ensembl
ENSG00000140545
NCBI Gene
Aliases
BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q08431Lactadherin3871Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453617Q08431Espacenet
WO 2025259600 A22025-12-1895Q08431Espacenet
EP 4650780 A22025-11-192649Q08431Espacenet
EP 4641201 A22025-10-292232Q08431Espacenet
EP 4641203 A22025-10-2988Q08431Espacenet
JP 2025147176 A2025-10-068639Q08431Espacenet
JP 2025147176 A2025-10-068640Q08431Espacenet
JP 2025529142 A2025-09-047022Q08431Espacenet
JP 2025124629 A2025-08-261Q08431Espacenet
US 12384828 B22025-08-12200Q08431Espacenet

1 to 10 of 73

See all 73 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BRE-3 90YCHEMBL2109363Lactadherin binding agentBINDING AGENT

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,863

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMFGE8 papersNewest fiscal year
ZIAAG000237Age-Associated Changes in Arterial Proteome and Aortic Smooth Muscle Signaling102025
ZIAAG000240Progression of Arterial Aging: the Local MCP-1/MMP-2/TGF-beta 1 Signaling Loop92025
R35GM118337Novel Approaches to Maintaining Organ Function in Sepsis72025
ZIAAG000236Calpain-1 Activity and Central Arterial Aging62025
ZIAAG000239Effect of Metalloprotease Inhibition on Age-Associated Arterial Remodeling62025
P30EY007003University of Michigan Vision Research Center52025
R01HL076179Improvement of Organ Function after Severe Hypovolemia52025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE42025
P30CA008748Cancer Center Support Grant42025
P30CA016058Cancer Center Support Grant42025

1 to 10 of 1,863Source NIH's project files

See all 1,863 nih grants

Papers3,015

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Rapamycin attenuates ferroptotic stress and improves macrophage efferocytosis in experimental atherosclerosis.Int Immunopharmacol202642826448PubTator, text miningPubMed
3D-Printed DOX-LF-Loaded PLGA Biphasic Composite Scaffold Modulates Macrophage Polarization and Enhances Osteogenic-Angiogenic Regenerative Potential for Periodontitis.Front Biosci (Landmark Ed)202642811969PubTator, text miningPubMed
MFG-E8 glycoprotein in inflammatory tissue regeneration: molecular mechanisms, therapeutic potential and advanced polymeric biomaterial delivery strategies.J Biomater Sci Polym Ed202642803719PubTator, text miningPubMed
Defective m6A RNA modification in macrophages exacerbates inflammation and promotes colitis-associated carcinogenesis by impairing efferocytosis.Cancer Lett202642498074PubTator, text miningPubMed
Bioactive components in preterm and term human milk compared to donor human milk: A pilot study.Clin Nutr ESPEN202642486403PubTator, text miningPubMed
Medin-Induced Pro-inflammatory and Prothrombotic Activation of Coronary Artery Endothelial Cells: A Potential Novel Mediator Linking Aging and Atherosclerosis.bioRxiv202642465488PubTator, text miningPubMed
Metabolic regulatory mechanisms of Yijinjing exercise in patients with type 2 diabetes mellitus: Insight from the gut microbiota-intestinal barrier- inflammation axis.Front Endocrinol (Lausanne)202642422424PubTator, text miningPubMed
Inter-tissue relationships of gene expression in liver, muscle and adipose tissue of children with end-stage chronic liver disease.J Pediatr Gastroenterol Nutr202642403289PubTator, text miningPubMed
Multimodal Proteomics Reveals Dysregulated Secretion and ECM Remodelling in Schizophrenia Patient iPSC-Derived Astrocytes.Cells202642346080PubTator, text miningPubMed
Multilevel Proteome Analysis Reveals the Region-specific Components of the Human Milk Fat Globule Membrane in China.J Agric Food Chem202642332366PubTator, text miningPubMed

1 to 10 of 3,015

See all 3,015 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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