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Gene · 4245

MGAT1: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MGAT1: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase. Genes, record 4245. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4245

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Gene

Symbol
MGAT1
HGNC
Name
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
HGNC
NCBI Gene ID
4245
NCBI Gene
HGNC ID
HGNC:7044
HGNC
Ensembl
ENSG00000131446
NCBI Gene
Aliases
GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, GnTI, MGAT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P26572Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase4450Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452559P26572Espacenet
JP 2026004568 A2026-01-1452560P26572Espacenet
JP 2026004568 A2026-01-1452561P26572Espacenet
JP 2026004568 A2026-01-1452562P26572Espacenet
JP 2026004568 A2026-01-1452563P26572Espacenet
EP 4650780 A22025-11-194792P26572Espacenet
JP 2025529142 A2025-09-042631P26572Espacenet
US 12371689 B22025-07-292631P26572Espacenet
JP 2025517970 A2025-06-124792P26572Espacenet
WO 2025093745 A12025-05-0827P26572Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,268

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMGAT1 papersNewest fiscal year
R01CA206573Structure and function of Transient Receptor Potential Channels152025
R01GM083144Characterization of mammalian COG complex-interacting Golgi trafficking machinery132025
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States122025
ZIAAI005022Antibody Neutralization Mechanisms122025
R01HL103411Systems Biology of Glycosylation112025
ZICAI005112Computational Tools for Structural Analysis112025
ZIAAI005024Design Of Immunogens102025
ZICAI005111Design of Antigenically-Specific Probes for Sera Analysis and MAb Isolation102025
UM1AI144462Consortium for HIV/AIDS Vaccine Development92025
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography72025

1 to 10 of 1,268Source NIH's project files

See all 1,268 nih grants

Papers1,299

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic and biochemical screens identify MGAT1 as a druggable glycosyltransferase target in STK11-mutant lung cancer.J Biol Chem202642727848PubTator, text miningPubMed
Mutations in the N-glycan branching enzyme MGAT1 promote invasiveness and EGF-stimulated proliferation and adhesion in neuroblastoma cells.PLoS One202642721203PubTator, text miningPubMed
Profiling neoadjuvant therapy response in rectal cancer using meta-analysis of publicly available transcriptomic RNA-seq datasets.Mol Oncol202642703166PubTator, text miningPubMed
Iterative Bump-and-Hole Engineering Creates a Bioorthogonal Reporter for N-Acetylglucosaminyltransferase I.J Am Chem Soc202642378460PubTator, text miningPubMed
mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model.Proc Natl Acad Sci U S A202642258728PubTator, text miningPubMed
Statement of Retraction: MicroRNA miR-331-3p suppresses osteosarcoma progression via the Bcl-2/Bax and Wnt/β-Catenin signaling pathways and the epithelial-mesenchymal transition by targeting N-acetylglucosaminyltransferase I (MGAT1).
Bioengineered202642165821PubTator, text miningPubMed
Deleterious effects of perfluorooctanesulfonate (PFOS) exposure on glucose and lipid metabolisms in the marine water flea Diaphanosoma celebensis.Comp Biochem Physiol C Toxicol Pharmacol202641966289PubTator, text miningPubMed
A preliminary study developing a scoring model incorporating fibrinogen-like protein 2 for predicting glucocorticoid resistance in thyroid eye disease.Thyroid Res202641917995PubTator, text miningPubMed
Exploring sex bias in cardiometabolic diseases.Lipids Health Dis202641840637PubTator, text miningPubMed
N-Glycoengineering of insect cells for tri-antennary N-glycan biosynthesis.Sci Rep202641839924PubTator, text miningPubMed

1 to 10 of 1,299

See all 1,299 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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