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Library / Genes

MGMT: O-6-methylguanine-DNA methyltransferase

1 protein, 52 patents, 0 drugs, 0 trials, 4,827 NIH grants and 18,010 papers.

Gene 6

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMGMTHGNC
NameO-6-methylguanine-DNA methyltransferaseHGNC
NCBI Gene ID4255NCBI Gene
HGNC IDHGNC:7059HGNC
EnsemblENSG00000170430NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P16455Methylated-DNA--protein-cysteine methyltransferase20723Ensembl, GeneID, HGNCUniProt

Patents 52

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4731762 A22026-04-292P16455Espacenet
EP 4650780 A22025-11-1919746P16455Espacenet
JP 2025147176 A2025-10-0616596P16455Espacenet
JP 2025517970 A2025-06-1219746P16455Espacenet
JP 2025028160 A2025-02-2816596P16455Espacenet
KR 1020250010750 A2025-01-2116596P16455Espacenet
WO 2024252368 A22024-12-1263P16455Espacenet
JP 2024109657 A2024-08-1416435P16455Espacenet
US 11679121 B22023-06-205P16455Espacenet
US 11278629 B22022-03-2257P16455Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4827

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1002,025NIH's project files
P30CA008748Cancer Center Support Grant982,025NIH's project files
P30CA043703Case Comprehensive Cancer Center Support Grant602,025NIH's project files
P30CA006973Regional Oncology Research Center512,025NIH's project files
P50CA211015UCLA SPORE in Brain Cancer502,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)482,025NIH's project files
P50CA097257Brain Tumor SPORE Grant452,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award312,025NIH's project files
P50CA221747SPORE for Translational Approaches to Brain Cancer272,025NIH's project files
P30CA016058Cancer Center Support Grant262,025NIH's project files

Papers 18010

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823681PubTator, text miningPubMed
42821806PubTator, text miningPubMed
42817804PubTator, text miningPubMed
42817692PubTator, text miningPubMed
42811203PubTator, text miningPubMed
42809874PubTator, text miningPubMed
42808537PubTator, text miningPubMed
42801921PubTator, text miningPubMed
42794981PubTator, text miningPubMed
42792786PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license