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Gene · 4256

MGP: matrix Gla protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MGP: matrix Gla protein. Genes, record 4256. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4256

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Gene

Symbol
MGP
HGNC
Name
matrix Gla protein
HGNC
NCBI Gene ID
4256
NCBI Gene
HGNC ID
HGNC:7060
HGNC
Ensembl
ENSG00000111341
NCBI Gene
Aliases
GIG36, MGLAP, NTI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08493Matrix Gla protein1033Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452736P08493Espacenet
EP 4650780 A22025-11-1916409P08493Espacenet
JP 2025147176 A2025-10-068696P08493Espacenet
JP 2025529142 A2025-09-047029P08493Espacenet
US 12371689 B22025-07-297029P08493Espacenet
JP 2025517970 A2025-06-1216409P08493Espacenet
JP 2025032204 A2025-03-1131572P08493Espacenet
JP 2025028160 A2025-02-288696P08493Espacenet
KR 1020250010750 A2025-01-218696P08493Espacenet
EP 4461818 A22024-11-1331572P08493Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,562

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMGP papersNewest fiscal year
R01HL081397Mechanism of Matrix Gla Protein (MGP); Adipose Fibrosis292025
R01NS079353BMP and Notch crosstalk in cerebral arteriovenous malformations182025
R01HL139675Switch of Osteogenesis in Vascular Calcification92025
P30AG021332Wake Forest Claude D. Pepper OAIC - Renewal62025
P30EY005722Center Core Grant for Vision Research62025
T32AR007592Interdisciplinary Training Program in Muscle Biology62025
P30DK017047Diabetes Research Center52025
P30EY008098Core Grant for Vision Research52025
P30EY010572Ophthalmology Core Facility52025
R01HL158053Endothelial Regulation of Vascular Calcification52025

1 to 10 of 1,562Source NIH's project files

See all 1,562 nih grants

Papers3,332

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated Multi-Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC.Adv Sci (Weinh)202642801661PubTator, text miningPubMed
Regulators of Mineralization and Long-Term Progression of Aortic Valve and Mitral Annular Calcification: MESA.J Am Heart Assoc202642786596PubTator, text miningPubMed
A Multifunctional Mesoporous Janus Separator With Optimized Mass Transport Regulation Enabling 800-Cycle Lithium-Oxygen Batteries.Adv Sci (Weinh)202642733227PubTator, text miningPubMed
Circulating matrix GLA protein during puberty in healthy and central precocious puberty children.Endocr Connect202642696275PubTator, text miningPubMed
Beyond Bone Health: Exploring the "Heart-Brain-Bone" Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2).Nutrients202642654291PubTator, text miningPubMed
Polyaspartic Acid-Doped With Robust Polymerized Hydrogel Armor Enhances Anti-Calcification of Decellularized Porcine Heart Valves.Adv Healthc Mater202642638230PubTator, text miningPubMed
Caspase-8 as a candidate mediator associated with everolimus resistance in neuroendocrine tumors.J Mol Endocrinol202642615220PubTator, text miningPubMed
Mitochondrial RNA modification in colorectal cancer: From single-cell analysis to machine learning-based risk modeling.Comput Biol Chem202642600521PubTator, text miningPubMed
Single-Cell atlas of aqueous humor outflow in glaucomatous Non-Human Primates identified MGP as a regulator of ECM remodeling.Exp Eye Res202642562148PubTator, text miningPubMed
From proteome-wide Mendelian randomization and multi-omics integration to functional validation: TGFB3 as a prioritized candidate in gastric adenocarcinoma.Front Oncol202642518818PubTator, text miningPubMed

1 to 10 of 3,332

See all 3,332 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4256

GET https://conductscience.org/api/genes/v1/4256/patents?page=2