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Gene · 4277

MICB: MHC class I polypeptide-related sequence B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MICB: MHC class I polypeptide-related sequence B. Genes, record 4277. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4277

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Gene

Symbol
MICB
HGNC
Name
MHC class I polypeptide-related sequence B
HGNC
NCBI Gene ID
4277
NCBI Gene
HGNC ID
HGNC:7091
HGNC
Ensembl
ENSG00000204516
NCBI Gene
Aliases
PERB11.2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q29980MHC class I polypeptide-related sequence B3832Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026021336 A2026-02-1010Q29980Espacenet
JP 2026004568 A2026-01-1453453Q29980Espacenet
JP 2026004568 A2026-01-1453466Q29980Espacenet
JP 2026500896 A2026-01-0924Q29980Espacenet
EP 4650780 A22025-11-191378Q29980Espacenet
WO 2025235604 A12025-11-1324Q29980Espacenet
WO 2025235605 A12025-11-1324Q29980Espacenet
EP 4640849 A22025-10-29159Q29980Espacenet
EP 4641201 A22025-10-291010Q29980Espacenet
WO 2025177214 A12025-08-2836Q29980Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,015

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMICB papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
R01CA238039Therapeutic Targeting of Immune Evasion from the MICA - NKG2D Pathway92025
P01CA111412NK cells, their receptors and cancer therapy82025
P30CA016056Roswell Park Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant82025
P30CA023108Cancer Center Support Grant82025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer72025
R01AI021640Molecular Aspects of Cytomegalovirus Latency72025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro72025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies62025

1 to 10 of 2,015Source NIH's project files

See all 2,015 nih grants

Papers3,381

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Synergistic restoration of NK cell cytotoxicity against solid tumors via sLTA-mediated dual-action modulation.Mol Biol Rep202642747644PubTator, text miningPubMed
Tissue MICA/B expression and serum soluble MICA in cholangiocarcinoma: Associations with survival and advanced disease.Biomol Biomed202642745720PubTator, text miningPubMed
Identification of Critical Genes for Recurrent Aphthous Ulcer by Transcriptome Data Analysis and Mendelian Randomization.Oral Health Prev Dent202642714320PubTator, text miningPubMed
Antibodies to Non-HLA Antigens and Their Role in Organ Transplant Rejection.Int J Immunogenet202642615342PubTator, text miningPubMed
Plasma Proteomic Insights into the Digestive System Disorders Unveil Causal Associations and Drug Repurposing Targets.Phenomics202642614597PubTator, text miningPubMed
[Establishment of a Doxorubicin-Resistant Acute Myeloid Leukemia Cell Line and Study on Its Drug Resistance Mechanisms].Zhongguo Shi Yan Xue Ye Xue Za Zhi202642544649PubTator, text miningPubMed
Characterizing the impact of plasma protein levels on human brain structure and disorders leveraging integrative multi-omics analysis.medRxiv202642528609PubTator, text miningPubMed
Immunogenetic and Transcriptomic Evidence Implicating the NKG2D-MICA/MICB Axis in CALR-Mutated Myeloproliferative Neoplasms.Cancers (Basel)202642449598PubTator, text miningPubMed
Coordinated Roles of T Cells and Natural Killer Cells in Tumor Immunity.Curr Cancer Drug Targets202642381329PubTator, text miningPubMed
Expanded Allelic Diversity of Non-Classical HLA Class I and MIC Loci Identified Using Full-Gene Hybrid Capture-Based Next-Generation Sequencing.HLA202642366455PubTator, text miningPubMed

1 to 10 of 3,381

See all 3,381 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4277

GET https://conductscience.org/api/genes/v1/4277/patents?page=2