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MIF: macrophage migration inhibitory factor

1 protein, 133 patents, 2 drugs, 24 trials, 4,914 NIH grants and 12,274 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMIFHGNC
Namemacrophage migration inhibitory factorHGNC
NCBI Gene ID4282NCBI Gene
HGNC IDHGNC:7097HGNC
EnsemblENSG00000240972NCBI Gene
AliasesGIF, GLIF, MMIFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14174Macrophage migration inhibitory factor115118Ensembl, GeneID, HGNCUniProt

Patents 133

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452200P14174Espacenet
EP 4650780 A22025-11-19276P14174Espacenet
JP 2025517970 A2025-06-12276P14174Espacenet
JP 2025506727 A2025-03-1327P14174Espacenet
EP 4484957 A12025-01-0125P14174Espacenet
WO 2024252368 A22024-12-12182P14174Espacenet
JP 2023123507 A2023-09-05210P14174Espacenet
WO 2023162878 A2023-08-3125P14174Espacenet
JP 2023515708 A2023-04-1338P14174Espacenet
JP 2023504620 A2023-02-06144P14174Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IGURATIMODCHEMBL2107455Macrophage migration inhibitory factor inhibitorINHIBITORChEMBL
IMALUMABCHEMBL4650294Macrophage migration inhibitory factor inhibitorINHIBITORChEMBL

Trials 24

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07115641IGURATIMODClinicalTrials.gov
NCT07057778IGURATIMODPHASE2ClinicalTrials.gov
NCT06945666IGURATIMODPHASE4ClinicalTrials.gov
NCT06244628IGURATIMODPHASE3ClinicalTrials.gov
NCT06146972IGURATIMODPHASE4ClinicalTrials.gov
NCT05803135IGURATIMODPHASE4ClinicalTrials.gov
NCT05789030IGURATIMODClinicalTrials.gov
NCT05302024IGURATIMODPHASE2ClinicalTrials.gov
NCT05281068IGURATIMODPHASE2ClinicalTrials.gov
NCT05216757IGURATIMODPHASE2/PHASE3ClinicalTrials.gov

NIH grants 4914

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UL1TR001863Yale Clinical and Translational Science Award462,025NIH's project files
P30CA016672Cancer Center Support Grant372,025NIH's project files
P51OD011104Tulane National Primate Research Center152,025NIH's project files
P30CA008748Cancer Center Support Grant142,025NIH's project files
P51OD011092Support for National Primate Research Center132,025NIH's project files
P30CA047904Cancer Center Support Grant122,025NIH's project files
P30CA016359Cancer Center Support Grant102,025NIH's project files
P30CA016058Cancer Center Support Grant92,025NIH's project files
D43TW005884Training and Research on Severe Malarial Anemia82,025NIH's project files
P30CA044579University of Virginia Cancer Center Support Grant82,025NIH's project files

Papers 12274

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42812459PubTator, text miningPubMed
42808769PubTator, text miningPubMed
42803078PubTator, text miningPubMed
42793025PubTator, text miningPubMed
42791421PubTator, text miningPubMed
42782368PubTator, text miningPubMed
42780883PubTator, text miningPubMed
42780569PubTator, text miningPubMed
42769912PubTator, text miningPubMed
42755419PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license