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Gene · 4284

MIP: major intrinsic protein of lens fiber

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MIP: major intrinsic protein of lens fiber. Genes, record 4284. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4284

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Gene

Symbol
MIP
HGNC
Name
major intrinsic protein of lens fiber
HGNC
NCBI Gene ID
4284
NCBI Gene
HGNC ID
HGNC:7103
HGNC
Ensembl
ENSG00000135517
NCBI Gene
Aliases
AQP0, CTRCT15, LIM1, MIP26, MP26
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30301Lens fiber major intrinsic protein2630Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452453P30301Espacenet
JP 2025529142 A2025-09-042650P30301Espacenet
US 12371689 B22025-07-292650P30301Espacenet
US 11446398 B22022-09-2048812P30301Espacenet
US 11400116 B22022-08-023696P30301Espacenet
JP 2022524081 A2022-04-27151783P30301Espacenet
US 11078247 B22021-08-036824P30301Espacenet
JP 2019054813 A2019-04-11232888P30301Espacenet
JP 2017523130 A2017-08-1710P30301Espacenet
JP 2017121241 A2017-07-13232888P30301Espacenet

1 to 10 of 13

See all 13 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,554

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMIP papersNewest fiscal year
R01EY013462The Role of Aquaporins in Lens Structure and Function402025
P30EY008126Core Grant in Vision Research232025
R01EY012085Intercellular Communication in the Eye Lens102025
ZIAEY000281Clinical/molecular Studies In Families With Congenital Or Hereditary Cataracts92025
P30EY004068Core Grant for Vision Research82025
R01EY030067Interaction of alpha-crystallin with cholesterol bilayer domains in cataract formation62025
P30CA091842Cancer Center Support Grant52025
P30EY005722Center Core Grant for Vision Research52025
R01EY012200Pax6 as a key regulator of lens development52025
P20GM103446Delaware INBRE42025

1 to 10 of 1,554Source NIH's project files

See all 1,554 nih grants

Papers2,928

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Initialize to Generalize: A Stronger Initialization Pipeline for Sparse-View 3DGS.IEEE Trans Vis Comput Graph202642771627PubTator, text miningPubMed
Analytical applications of molecularly imprinted polymers: a personal view.Anal Bioanal Chem202642766116PubTator, text miningPubMed
Redistribution of Aquaporin Proteins in Retinal Blood Vessels in Human Diabetic Retinopathy.Curr Eye Res202642720123PubTator, text miningPubMed
Immunotherapeutic effect of MIP vaccine along with multidrug therapy (MDT) in leprosy: A systematic review and meta-analysis.Indian J Med Res202642690855PubTator, text miningPubMed
A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence.Cell Commun Signal202642343301PubTator, text miningPubMed
A twin enrichment method based on dual-template molecularly imprinted polymer and dispersive liquid-liquid microextraction for simultaneous determination of two COVID-19 medicines in biological fluids.
J Chromatogr B Analyt Technol Biomed Life Sci202642322756PubTator, text miningPubMed
Follicular Fluid Meiosis-Activating Sterol (FF-MAS) Enhances Lens Transparency By Increasing αA-Crystallin Solubility In Cataracts.J Vis Exp202642296026PubTator, text miningPubMed
Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease.Cardiovasc Res202642156223PubTator, text miningPubMed
The Multifunctional Roles of Aquaporins in Tumors: Focusing on Metabolism, Migration, and Regulation of the Tumor Microenvironment.Int J Mol Sci202641977205PubTator, text miningPubMed
Transcriptional and post-translational regulation of aquaporins in plants.Stress Biol202641973391PubTator, text miningPubMed

1 to 10 of 2,928

See all 2,928 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4284

GET https://conductscience.org/api/genes/v1/4284/patents