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MLH1: mutL homolog 1

1 protein, 93 patents, 0 drugs, 0 trials, 5,308 NIH grants and 19,969 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMLH1HGNC
NamemutL homolog 1HGNC
NCBI Gene ID4292NCBI Gene
HGNC IDHGNC:7127HGNC
EnsemblENSG00000076242NCBI Gene
AliasesCOCA2, FCC2, HNPCC, HNPCC2, LYNCH2, MLH-1, MMRCS1, hMLH1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P40692DNA mismatch repair protein Mlh175611Ensembl, GeneID, HGNCUniProt

Patents 93

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4709870 A12026-03-18157P40692Espacenet
EP 4650780 A22025-11-19817P40692Espacenet
JP 2025517970 A2025-06-12817P40692Espacenet
JP 2024543481 A2024-11-21157P40692Espacenet
EP 4464338 A22024-11-20352P40692Espacenet
JP 2024542790 A2024-11-159P40692Espacenet
EP 4430207 A12024-09-18157P40692Espacenet
JP 2024123008 A2024-09-107125P40692Espacenet
US 11976334 B22024-05-07165P40692Espacenet
JP 2023098973 A2023-07-1112P40692Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5308

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2392,025NIH's project files
P30CA016672Cancer Center Support Grant2282,025NIH's project files
P30CA016058Cancer Center Support Grant1242,025NIH's project files
P30CA006973Regional Oncology Research Center712,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant592,025NIH's project files
P30CA015704Cancer Center Support Grant592,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award462,025NIH's project files
U01CA167551Colon Cancer Family Registry Cohort452,025NIH's project files
R01GM050006Enzymology of Mismatch Repair in Yeast342,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase332,025NIH's project files

Papers 19969

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822083PubTator, text miningPubMed
42821536PubTator, text miningPubMed
42811745PubTator, text miningPubMed
42809083PubTator, text miningPubMed
42802819PubTator, text miningPubMed
42801369PubTator, text miningPubMed
42798309PubTator, text miningPubMed
42794913PubTator, text miningPubMed
42790840PubTator, text miningPubMed
42790443PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license