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KMT2A: lysine methyltransferase 2A

1 protein, 34 patents, 2 drugs, 24 trials, 6,891 NIH grants and 16,262 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKMT2AHGNC
Namelysine methyltransferase 2AHGNC
NCBI Gene ID4297NCBI Gene
HGNC IDHGNC:7132HGNC
EnsemblENSG00000118058NCBI Gene
AliasesALL-1, ALL1, CXXC7, GAS7, HRX, HTRX, HTRX1, MLL, MLL1, MLL1A, TRX1, WDSTSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q03164Histone-lysine N-methyltransferase 2A3,96960Ensembl, GeneID, HGNCUniProt

Patents 34

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454437Q03164Espacenet
EP 4650780 A22025-11-1910688Q03164Espacenet
EP 4641201 A22025-10-2911092Q03164Espacenet
JP 2025147176 A2025-10-0615224Q03164Espacenet
JP 2025517969 A2025-06-1211092Q03164Espacenet
JP 2025517970 A2025-06-1210688Q03164Espacenet
JP 2025028160 A2025-02-2815224Q03164Espacenet
KR 1020250010750 A2025-01-2115224Q03164Espacenet
JP 2024109657 A2024-08-1415063Q03164Espacenet
JP 2023549761 A2023-11-29234Q03164Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
REVUMENIBCHEMBL4650827Menin/Histone-lysine N-methyltransferase MLL inhibitorINHIBITORChEMBL
REVUMENIB SESQUIFUMARATECHEMBL4650278Menin/Histone-lysine N-methyltransferase MLL inhibitorINHIBITORChEMBL

Trials 24

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605949REVUMENIBPHASE2ClinicalTrials.gov
NCT07563010REVUMENIBPHASE2ClinicalTrials.gov
NCT07498465REVUMENIBPHASE1ClinicalTrials.gov
NCT07356154REVUMENIBPHASE1/PHASE2ClinicalTrials.gov
NCT07283640REVUMENIBPHASE1ClinicalTrials.gov
NCT07211958REVUMENIBPHASE3ClinicalTrials.gov
NCT07052994REVUMENIBPHASE1ClinicalTrials.gov
NCT06652438REVUMENIBPHASE3ClinicalTrials.gov
NCT06575296REVUMENIBPHASE1ClinicalTrials.gov
NCT06313437REVUMENIBPHASE1ClinicalTrials.gov

NIH grants 6891

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2492,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)2042,025NIH's project files
P30CA016672Cancer Center Support Grant1622,025NIH's project files
P30CA016058Cancer Center Support Grant822,025NIH's project files
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement732,025NIH's project files
U10CA180899Children's Oncology Group Statistics and Data Center712,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias682,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant362,025NIH's project files
R35CA197695Translating genomic discoveries to improved outcomes for high risk acute leukemia322,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028302,025NIH's project files

Papers 16262

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818186PubTator, text miningPubMed
42814654PubTator, text miningPubMed
42809184PubTator, text miningPubMed
42805358PubTator, text miningPubMed
42801681PubTator, text miningPubMed
42795012PubTator, text miningPubMed
42780509PubTator, text miningPubMed
42780029PubTator, text miningPubMed
42779343PubTator, text miningPubMed
42769020PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license