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Gene · 4298

MLLT1: MLLT1 super elongation complex subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MLLT1: MLLT1 super elongation complex subunit. Genes, record 4298. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4298

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Gene

Symbol
MLLT1
HGNC
Name
MLLT1 super elongation complex subunit
HGNC
NCBI Gene ID
4298
NCBI Gene
HGNC ID
HGNC:7134
HGNC
Ensembl
ENSG00000130382
NCBI Gene
Aliases
ENL, LTG19, YEATS1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q03111Protein ENL55926Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454441Q03111Espacenet
EP 4650780 A22025-11-191403Q03111Espacenet
EP 4641201 A22025-10-291035Q03111Espacenet
JP 2025147176 A2025-10-0615297Q03111Espacenet
JP 2025517969 A2025-06-121035Q03111Espacenet
JP 2025517970 A2025-06-121403Q03111Espacenet
JP 2025028160 A2025-02-2815297Q03111Espacenet
EP 4496590 A12025-01-291Q03111Espacenet
KR 1020250010750 A2025-01-2115297Q03111Espacenet
JP 2024109657 A2024-08-1415136Q03111Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants916

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMLLT1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)172025
P30CA008748Cancer Center Support Grant162025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement142025
U10CA180899Children's Oncology Group Statistics and Data Center122025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias92025
P30CA016058Cancer Center Support Grant82025
P30AI027763UCSF-Bay Area Center for AIDS Research72025
P30CA016672Cancer Center Support Grant72025
P30CA091842Cancer Center Support Grant52025
R01CA193466Computational and Experimental Modeling of Alternative Polyadenylation52025

1 to 10 of 916Source NIH's project files

See all 916 nih grants

Papers1,351

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcription pause and elongation regulators mediate somatic hypermutation.Nature202642816608PubTator, text miningPubMed
Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell Chem Biol202642586062PubTator, text miningPubMed
Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes.bioRxiv202642523331PubTator, text miningPubMed
Context-dependent YEATS-domain inhibition enhances neuronal resilience and improves ALS phenotypes.Neurobiol Dis202642508735PubTator, text miningPubMed
RNA as a reinforcing node in condensate formation.Mol Cell202642462699PubTator, text miningPubMed
Lysine β-hydroxybutyrylation: A metabolic-epigenetic interface in health and disease.Phytomedicine202642284641PubTator, text miningPubMed
The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis.Cell Rep202642268713PubTator, text miningPubMed
Inhibition of MLLT1 Limits Growth of KMT2A::AFF1 Leukemias Without Killing Healthy Hematopoietic Stem Cells.Exp Hematol202642242459PubTator, text miningPubMed
Synthesis, structure-activity relationships, antitumor activities and mechanistic studies of ENL-degrading compounds.Eur J Med Chem202642218837PubTator, text miningPubMed
Discovery of selenium-containing amino acid derivatives as novel ENL YEATS domain inhibitors via AlphaScreen-based high throughput screening.Bioorg Chem202642150408PubTator, text miningPubMed

1 to 10 of 1,351

See all 1,351 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4298

GET https://conductscience.org/api/genes/v1/4298/patents