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Gene · 4299

AFF1: ALF transcription elongation factor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AFF1: ALF transcription elongation factor 1. Genes, record 4299. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4299

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Gene

Symbol
AFF1
HGNC
Name
ALF transcription elongation factor 1
HGNC
NCBI Gene ID
4299
NCBI Gene
HGNC ID
HGNC:7135
HGNC
Ensembl
ENSG00000172493
NCBI Gene
Aliases
AF-4, AF4, FEL, MLLT2, PBM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51825AF4/FMR2 family member 11,2101Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-293907P51825Espacenet
JP 2025147176 A2025-10-0614727P51825Espacenet
JP 2025517969 A2025-06-123907P51825Espacenet
JP 2025062604 A2025-04-143593P51825Espacenet
JP 2025028160 A2025-02-2814727P51825Espacenet
KR 1020250010750 A2025-01-2114727P51825Espacenet
JP 2024123008 A2024-09-104809P51825Espacenet
JP 2024109657 A2024-08-1414566P51825Espacenet
US 11446398 B22022-09-203593P51825Espacenet
JP 2022524081 A2022-04-27106564P51825Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,290

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAFF1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)352025
P30CA008748Cancer Center Support Grant122025
P30CA016672Cancer Center Support Grant112025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement112025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias92025
U10CA180899Children's Oncology Group Statistics and Data Center92025
R01CA157644Central tolerance mechanisms in B-cell malignancies72025
P30AI027763UCSF-Bay Area Center for AIDS Research62025
P30CA016042Cancer Center Support Grant62025
P42ES004705Toxic substances in the environment52025

1 to 10 of 1,290Source NIH's project files

See all 1,290 nih grants

Papers2,225

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: Circular RNA hsa_circ_0057452 facilitates keloid progression by targeting the microRNA-1225-3p/AF4/FMR2 family member 4 axis.Bioengineered202642826093PubTator, text miningPubMed
Glycosylation-Associated Macrophage Signatures Define a Diagnostic Model for Diabetic Retinopathy via Single-Cell Analysis.J Ophthalmol202642662694PubTator, text miningPubMed
A novel KMT2A::AFF1-derived fusion circRNA regulates mitochondrial metabolism in t(4;11) B-cell acute lymphoblastic leukemia.Haematologica202642610417PubTator, text miningPubMed
Influence of IGF2BP3 on t(4;11) fusion mRNA and protein abundance.Leuk Res202642537480PubTator, text miningPubMed
Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes.bioRxiv202642523331PubTator, text miningPubMed
The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis.Cell Rep202642268713PubTator, text miningPubMed
Inhibition of MLLT1 Limits Growth of KMT2A::AFF1 Leukemias Without Killing Healthy Hematopoietic Stem Cells.Exp Hematol202642242459PubTator, text miningPubMed
An integrated multi-omics analysis reveals a core epigenetically-activated transcriptional network driving oncogenic signaling in acute myeloid leukemia.Discov Oncol202642217088PubTator, text miningPubMed
Multi-stage transcriptome analysis identifies hub genes and regulatory mechanisms driving cervical cancer progression.PeerJ202642180604PubTator, text miningPubMed
Characterizing the impact of MLL fusion variants and fusion partners on leukemia plasticity using a human CRISPR-engineered MLL-rearranged leukemia model.Neoplasia202642001795PubTator, text miningPubMed

1 to 10 of 2,225

See all 2,225 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4299

GET https://conductscience.org/api/genes/v1/4299/patents?page=2