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Gene · 4300

MLLT3: MLLT3 super elongation complex subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MLLT3: MLLT3 super elongation complex subunit. Genes, record 4300. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4300

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Gene

Symbol
MLLT3
HGNC
Name
MLLT3 super elongation complex subunit
HGNC
NCBI Gene ID
4300
NCBI Gene
HGNC ID
HGNC:7136
HGNC
Ensembl
ENSG00000171843
NCBI Gene
Aliases
AF-9, AF9, YEATS3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42568Protein AF-956826Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454446P42568Espacenet
JP 2025147176 A2025-10-0615300P42568Espacenet
JP 2025028160 A2025-02-2815300P42568Espacenet
KR 1020250010750 A2025-01-2115300P42568Espacenet
JP 2024109657 A2024-08-1415139P42568Espacenet
US 11845959 B22023-12-193P42568Espacenet
US 11564942 B22023-01-3147P42568Espacenet
US 11446398 B22022-09-2054071P42568Espacenet
JP 2022524081 A2022-04-27157042P42568Espacenet
JP 2021536249 A2021-12-2715493P42568Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,646

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMLLT3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant372025
P30CA021765Cancer Center Support Grant (CCSG)292025
P30CA016672Cancer Center Support Grant222025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias172025
P30CA016058Cancer Center Support Grant112025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant102025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement102025
U10CA180899Children's Oncology Group Statistics and Data Center92025
P30CA091842Cancer Center Support Grant72025
P30AI027763UCSF-Bay Area Center for AIDS Research62025

1 to 10 of 1,646Source NIH's project files

See all 1,646 nih grants

Papers2,395

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcription pause and elongation regulators mediate somatic hypermutation.Nature202642816608PubTator, text miningPubMed
CD56-Positive Acute Myeloid Leukemia Complicated by Hemophagocytic Lymphohistiocytosis: A case report and narrative review.Pak J Med Sci202642668947PubTator, text miningPubMed
A novel role for transcription factor NFE2 in redox regulation and chemotherapy resistance in acute myeloid leukemia.Leukemia202642618699PubTator, text miningPubMed
Effect of the Proteasome Inhibitor, Bortezomib, on Histone Modifications in Human Leukemic Cell Lines.Int J Mol Sci202642589252PubTator, text miningPubMed
Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell Chem Biol202642586062PubTator, text miningPubMed
Targeting a CDH1-TK1-dependent DNA Synthesis Pathway Overcomes Chemoresistance in Acute Myeloid Leukemia.Hematol Oncol202642570285PubTator, text miningPubMed
Targeting the PRMT1 axis in cancer: from epigenetic plasticity to contextual therapeutic interventions.Front Oncol202642523618PubTator, text miningPubMed
Context-dependent YEATS-domain inhibition enhances neuronal resilience and improves ALS phenotypes.Neurobiol Dis202642508735PubTator, text miningPubMed
Phosphorylated DEK sustains leukemia stem cells by enabling PBX3-driven transcriptional reprogramming.Blood202642378254PubTator, text miningPubMed
The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis.Cell Rep202642268713PubTator, text miningPubMed

1 to 10 of 2,395

See all 2,395 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4300

GET https://conductscience.org/api/genes/v1/4300/patents