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Gene · 4301

AFDN: afadin, adherens junction formation factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AFDN: afadin, adherens junction formation factor. Genes, record 4301. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4301

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Gene

Symbol
AFDN
HGNC
Name
afadin, adherens junction formation factor
HGNC
NCBI Gene ID
4301
NCBI Gene
HGNC ID
HGNC:7137
HGNC
Ensembl
ENSG00000130396
NCBI Gene
Aliases
AF-6, AF6, MLL-AF6, MLLT4, l-afadin
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P55196Afadin1,8246Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454454P55196Espacenet
EP 4641201 A22025-10-2915100P55196Espacenet
JP 2025147176 A2025-10-0615301P55196Espacenet
JP 2025517969 A2025-06-1215100P55196Espacenet
JP 2025028160 A2025-02-2815301P55196Espacenet
KR 1020250010750 A2025-01-2115301P55196Espacenet
JP 2024109657 A2024-08-1415140P55196Espacenet
US 12023385 B22024-07-0244P55196Espacenet
EP 4119552 A12023-01-1858P55196Espacenet
US 11446398 B22022-09-2054082P55196Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,132

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAFDN papersNewest fiscal year
R35GM118096Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesis132025
P30CA008748Cancer Center Support Grant122025
P30CA021765Cancer Center Support Grant (CCSG)92025
P30CA016672Cancer Center Support Grant82025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
R01DK079392Intestinal Inflammation: Signaling proteins and the rate of PMN transmigration52025
R01MH071316Rac-GEF signaling in dendritic spines52025
P30CA086862Cancer Center Support Grant42025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement42025

1 to 10 of 1,132Source NIH's project files

See all 1,132 nih grants

Papers1,720

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
AF6 orchestrates macrophage polarization via JAK2-STAT3 signaling and supports intestinal regeneration by stimulating stem cell proliferation.Front Immunol202642404906PubTator, text miningPubMed
[Preneoplastic and Neoplastic Small Lymphocytic Proliferations Concurrent with Acute Myeloid Leukemia: A Report of Four Cases].Zhongguo Shi Yan Xue Ye Xue Za Zhi202642227422PubTator, text miningPubMed
Strength in numbers: Proteins travel as condensates to reinforce cell-cell junctions under stress.J Cell Biol202642171593PubTator, text miningPubMed
p120-catenin downregulation selectively modulates inflammatory susceptibility in eyelid specimens of rosacea.Exp Eye Res202642114612PubTator, text miningPubMed
All-trans retinoic acid combined with the VAH regimen for EVI1-positive acute myeloid leukemia: a case report with a brief literature review.Front Oncol202642063737PubTator, text miningPubMed
Adherens junctions balance stability and motility: from cell morphogenesis to neural tissue patterning.Biol Chem202641955739PubTator, text miningPubMed
Edge-vertex flow enables rapid adhesion reinforcement under tension.J Cell Biol202641955013PubTator, text miningPubMed
Circular and Long Non-Coding RNAs in Cancer Metabolism: Dual Perspective of Biomarkers and Therapeutic Targets.Noncoding RNA202641874139PubTator, text miningPubMed
Mechanisms of active wetting and fluidification in epithelial cell collectives.Nat Mater202641872301PubTator, text miningPubMed
Interplay between flaviviruses and the interferon response: mechanisms of immune evasion and therapeutic implications.Front Pharmacol202641788799PubTator, text miningPubMed

1 to 10 of 1,720

See all 1,720 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4301

GET https://conductscience.org/api/genes/v1/4301/patents?page=2