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Gene · 4303

FOXO4: forkhead box O4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FOXO4: forkhead box O4. Genes, record 4303. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4303

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Gene

Symbol
FOXO4
HGNC
Name
forkhead box O4
HGNC
NCBI Gene ID
4303
NCBI Gene
HGNC ID
HGNC:7139
HGNC
Ensembl
ENSG00000184481
NCBI Gene
Aliases
AFX, AFX1, MLLT7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P98177Forkhead box protein O45052Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026097876 A2026-06-1639P98177Espacenet
JP 2026516078 A2026-05-191P98177Espacenet
EP 4709912 A12026-03-181P98177Espacenet
EP 4650780 A22025-11-199439P98177Espacenet
EP 4641201 A22025-10-299696P98177Espacenet
JP 2025147176 A2025-10-0615012P98177Espacenet
EP 4590323 A22025-07-3052P98177Espacenet
JP 2025517969 A2025-06-129696P98177Espacenet
JP 2025517970 A2025-06-129439P98177Espacenet
JP 2025028160 A2025-02-2815012P98177Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,544

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFOXO4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant132025
P30CA016672Cancer Center Support Grant112025
P01AG062413Targeting Cellular Senescence to Extend Healthspan92025
R37AG013925Effect of Aging on Preadipocyte Differentiation72025
P01AG036695Molecular Regulation of Stem Cell Aging52025
P30CA021765Cancer Center Support Grant (CCSG)52025
R01DE017732Diabetes-enhanced Experimental Periodontitis52025
P50CA217694SPORE in Soft Tissue Sarcoma42025
R33AG061456Translational Geroscience Network42025
T32CA009302Leveraging innovative technologies in basic and clinical cancer research42025

1 to 10 of 1,544Source NIH's project files

See all 1,544 nih grants

Papers2,706

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated bioinformatics analysis, machine learning, and experimental validation reveal that ACSL1 drives myocardial ischemia reperfusion injury via ferroptosis.J Bioenerg Biomembr202642782425PubTator, text miningPubMed
OGT-rearranged mesenchymal neoplasm of the palm with a novel C3orf62/MAPS partner gene: expanding the molecular spectrum of this rare entity.Virchows Arch202642734649PubTator, text miningPubMed
FOXO6 as a Transcriptional Regulator of Hepatic Metabolic Inflammation and Hepatocarcinogenesis.IUBMB Life202642665991PubTator, text miningPubMed
Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.iScience202642620746PubTator, text miningPubMed
FOXO4 enhances high glucose-induced HK-2 cell damage and inflammation by targeting TFPI2 in diabetic nephropathy.Kidney Res Clin Pract202642619388PubTator, text miningPubMed
Contrasting Effects of HT-2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism.J Biochem Mol Toxicol202642533448PubTator, text miningPubMed
FOXO4 as a Redox-Sensitive Regulator of Antioxidant Defense and Cellular Senescence: Cysteine-Based Signaling, p53 Interaction, and Therapeutic Targeting.Antioxidants (Basel)202642510573PubTator, text miningPubMed
NMR investigation of conformational heterogeneity in FOXO4 CR2C binding to the MLL site of CBP KIX.J Magn Reson202642472485PubTator, text miningPubMed
Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways.Aging Adv202642370305PubTator, text miningPubMed
FOXO family and neurodegenerative diseases: Mechanisms of action and therapeutic potential.Redox Biol202642202637PubTator, text miningPubMed

1 to 10 of 2,706

See all 2,706 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4303

GET https://conductscience.org/api/genes/v1/4303/patents?page=2