Gene · 4303
FOXO4: forkhead box O4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FOXO4: forkhead box O4. Genes, record 4303. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4303
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P98177 | Forkhead box protein O4 | 505 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026097876 A | 2026-06-16 | 39 | P98177 | Espacenet |
| JP 2026516078 A | 2026-05-19 | 1 | P98177 | Espacenet |
| EP 4709912 A1 | 2026-03-18 | 1 | P98177 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9439 | P98177 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9696 | P98177 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15012 | P98177 | Espacenet |
| EP 4590323 A2 | 2025-07-30 | 52 | P98177 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 9696 | P98177 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9439 | P98177 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15012 | P98177 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,544
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FOXO4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P01AG062413 | Targeting Cellular Senescence to Extend Healthspan | 9 | 2025 |
| R37AG013925 | Effect of Aging on Preadipocyte Differentiation | 7 | 2025 |
| P01AG036695 | Molecular Regulation of Stem Cell Aging | 5 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| R01DE017732 | Diabetes-enhanced Experimental Periodontitis | 5 | 2025 |
| P50CA217694 | SPORE in Soft Tissue Sarcoma | 4 | 2025 |
| R33AG061456 | Translational Geroscience Network | 4 | 2025 |
| T32CA009302 | Leveraging innovative technologies in basic and clinical cancer research | 4 | 2025 |
1 to 10 of 1,544Source NIH's project files
See all 1,544 nih grantsPapers2,706
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated bioinformatics analysis, machine learning, and experimental validation reveal that ACSL1 drives myocardial ischemia reperfusion injury via ferroptosis. | J Bioenerg Biomembr | 2026 | 42782425 | PubTator, text mining | PubMed |
| OGT-rearranged mesenchymal neoplasm of the palm with a novel C3orf62/MAPS partner gene: expanding the molecular spectrum of this rare entity. | Virchows Arch | 2026 | 42734649 | PubTator, text mining | PubMed |
| FOXO6 as a Transcriptional Regulator of Hepatic Metabolic Inflammation and Hepatocarcinogenesis. | IUBMB Life | 2026 | 42665991 | PubTator, text mining | PubMed |
| Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data. | iScience | 2026 | 42620746 | PubTator, text mining | PubMed |
| FOXO4 enhances high glucose-induced HK-2 cell damage and inflammation by targeting TFPI2 in diabetic nephropathy. | Kidney Res Clin Pract | 2026 | 42619388 | PubTator, text mining | PubMed |
| Contrasting Effects of HT-2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism. | J Biochem Mol Toxicol | 2026 | 42533448 | PubTator, text mining | PubMed |
| FOXO4 as a Redox-Sensitive Regulator of Antioxidant Defense and Cellular Senescence: Cysteine-Based Signaling, p53 Interaction, and Therapeutic Targeting. | Antioxidants (Basel) | 2026 | 42510573 | PubTator, text mining | PubMed |
| NMR investigation of conformational heterogeneity in FOXO4 CR2C binding to the MLL site of CBP KIX. | J Magn Reson | 2026 | 42472485 | PubTator, text mining | PubMed |
| Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways. | Aging Adv | 2026 | 42370305 | PubTator, text mining | PubMed |
| FOXO family and neurodegenerative diseases: Mechanisms of action and therapeutic potential. | Redox Biol | 2026 | 42202637 | PubTator, text mining | PubMed |
1 to 10 of 2,706
See all 2,706 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4303
GET https://conductscience.org/api/genes/v1/4303/patents?page=2