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NR3C2: nuclear receptor subfamily 3 group C member 2

1 protein, 34 patents, 18 drugs, 356 trials, 3,708 NIH grants and 9,174 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNR3C2HGNC
Namenuclear receptor subfamily 3 group C member 2HGNC
NCBI Gene ID4306NCBI Gene
HGNC IDHGNC:7979HGNC
EnsemblENSG00000151623NCBI Gene
AliasesMCR, MLR, MR, NR3C2VITNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08235Mineralocorticoid receptor98430Ensembl, GeneID, HGNCUniProt

Patents 34

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456166P08235Espacenet
JP 2026004568 A2026-01-1456168P08235Espacenet
EP 4640849 A22025-10-29957P08235Espacenet
EP 4641201 A22025-10-296397P08235Espacenet
EP 4641202 A22025-10-295153P08235Espacenet
JP 2025519096 A2025-06-24957P08235Espacenet
JP 2025517969 A2025-06-126397P08235Espacenet
JP 2025032204 A2025-03-1132465P08235Espacenet
JP 2025032204 A2025-03-1132466P08235Espacenet
KR 1020250017231 A2025-02-045153P08235Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BALCINRENONECHEMBL3916929Mineralocorticoid receptor modulatorMODULATORChEMBL
CANRENOATECHEMBL1616951Mineralocorticoid receptor antagonistANTAGONISTChEMBL
CANRENOATE POTASSIUMCHEMBL1371200Mineralocorticoid receptor antagonistANTAGONISTChEMBL
CANRENONECHEMBL1463345Mineralocorticoid receptor antagonistANTAGONISTChEMBL
DESOXYCORTICOSTERONE ACETATECHEMBL1200542Mineralocorticoid receptor agonistAGONISTChEMBL
DESOXYCORTICOSTERONE PIVALATECHEMBL1200592Mineralocorticoid receptor agonistAGONISTChEMBL
DROSPIRENONECHEMBL1509Mineralocorticoid receptor antagonistANTAGONISTChEMBL
EPLERENONECHEMBL1095097Mineralocorticoid receptor antagonistANTAGONISTChEMBL
FELODIPINECHEMBL1480Mineralocorticoid receptor antagonistANTAGONISTChEMBL
FINERENONECHEMBL2181927Mineralocorticoid receptor antagonistANTAGONISTChEMBL

Trials 356

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07598864FINERENONEPHASE3ClinicalTrials.gov
NCT07594145FINERENONEPHASE2ClinicalTrials.gov
NCT07575672FINERENONEPHASE3ClinicalTrials.gov
NCT07554469FINERENONEClinicalTrials.gov
NCT07539259SPIRONOLACTONEPHASE2ClinicalTrials.gov
NCT07536763DROSPIRENONEPHASE3ClinicalTrials.gov
NCT07473895SPIRONOLACTONEPHASE2ClinicalTrials.gov
NCT07431216SPIRONOLACTONEPHASE1/PHASE2ClinicalTrials.gov
NCT07415811SPIRONOLACTONEClinicalTrials.gov
NCT07379840FINERENONEClinicalTrials.gov

NIH grants 3708

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL119290Smooth Muscle Mineralocorticoid Receptor in Obesity-Induced Vascular Stiffness192,025NIH's project files
U54GM115428Mississippi Center for Clinical and Translational Research162,025NIH's project files
T32HL007457Mechanisms of Hypertension and Cardiovascular Diseases132,025NIH's project files
R01DK115392Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes112,025NIH's project files
P30CA008748Cancer Center Support Grant102,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)102,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award82,025NIH's project files
ZIAES090057Glucocorticoid Hormone Action72,025NIH's project files
P30CA006973Regional Oncology Research Center62,025NIH's project files
P30DK020595Diabetes Research and Training Center62,025NIH's project files

Papers 9174

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42812492PubTator, text miningPubMed
42806023PubTator, text miningPubMed
42802134PubTator, text miningPubMed
42800510PubTator, text miningPubMed
42794778PubTator, text miningPubMed
42791474PubTator, text miningPubMed
42779624PubTator, text miningPubMed
42770069PubTator, text miningPubMed
42768479PubTator, text miningPubMed
42765498PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license