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MME: membrane metalloendopeptidase

1 protein, 168 patents, 4 drugs, 108 trials, 6,947 NIH grants and 27,229 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMEHGNC
Namemembrane metalloendopeptidaseHGNC
NCBI Gene ID4311NCBI Gene
HGNC IDHGNC:7154HGNC
EnsemblENSG00000196549NCBI Gene
AliasesCALLA, CD10, CMT2T, NEP, SCA43, SFENCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08473Neprilysin75016Ensembl, GeneID, HGNCUniProt

Patents 168

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-297869P08473Espacenet
US 12441982 B22025-10-141P08473Espacenet
JP 2025529142 A2025-09-042660P08473Espacenet
US 12371689 B22025-07-292660P08473Espacenet
JP 2025517969 A2025-06-127869P08473Espacenet
EP 4549941 A12025-05-0715P08473Espacenet
JP 2025514209 A2025-05-021P08473Espacenet
EP 4514403 A22025-03-051P08473Espacenet
JP 2024123008 A2024-09-106937P08473Espacenet
JP 2024123008 A2024-09-106938P08473Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DAGLUTRILCHEMBL3989794Neprilysin inhibitorINHIBITORChEMBL
ILEPATRILCHEMBL3187812Neprilysin inhibitorINHIBITORChEMBL
RACECADOTRILCHEMBL2103772Neprilysin inhibitorINHIBITORChEMBL
SACUBITRILCHEMBL3137301Neprilysin inhibitorINHIBITORChEMBL

Trials 108

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07491718SACUBITRILClinicalTrials.gov
NCT07454421RACECADOTRILPHASE1/PHASE2ClinicalTrials.gov
NCT07444398SACUBITRILPHASE1ClinicalTrials.gov
NCT07341893SACUBITRILClinicalTrials.gov
NCT07261098SACUBITRILPHASE2ClinicalTrials.gov
NCT07192341SACUBITRILClinicalTrials.gov
NCT06716970SACUBITRILPHASE3ClinicalTrials.gov
NCT06712030SACUBITRILPHASE3ClinicalTrials.gov
NCT06693674SACUBITRILPHASE3ClinicalTrials.gov
NCT06643819SACUBITRILPHASE3ClinicalTrials.gov

NIH grants 6947

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1502,025NIH's project files
P30CA016672Cancer Center Support Grant1102,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)682,025NIH's project files
ZIASC000550Lymphoma Disease Discovery and Definition452,025NIH's project files
ZIABC011070Hematopathology Diagnosis412,025NIH's project files
P30CA006973Regional Oncology Research Center312,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award292,025NIH's project files
ZIEBC011241Hematopathology Fellowship242,025NIH's project files
ZIAAI000825Role of B Lymphocytes In HIV Infection And Pathogenesis222,025NIH's project files
P30AI073961Miami Center for AIDS Research192,025NIH's project files

Papers 27229

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824651PubTator, text miningPubMed
42823600PubTator, text miningPubMed
42819586PubTator, text miningPubMed
42814322PubTator, text miningPubMed
42813078PubTator, text miningPubMed
42811949PubTator, text miningPubMed
42806960PubTator, text miningPubMed
42806338PubTator, text miningPubMed
42799816PubTator, text miningPubMed
42799779PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license