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MMP1: matrix metallopeptidase 1

1 protein, 150 patents, 6 drugs, 191 trials, 7,545 NIH grants and 25,564 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMP1HGNC
Namematrix metallopeptidase 1HGNC
NCBI Gene ID4312NCBI Gene
HGNC IDHGNC:7155HGNC
EnsemblENSG00000196611NCBI Gene
AliasesCLGNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P03956Interstitial collagenase46915Ensembl, GeneID, HGNCUniProt

Patents 150

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026138951 A2026-08-315P03956Espacenet
US 12539325 B22026-02-0310P03956Espacenet
US 12539325 B22026-02-0313P03956Espacenet
JP 2026000906 A2026-01-06112P03956Espacenet
EP 4650780 A22025-11-195455P03956Espacenet
JP 2025147176 A2025-10-068761P03956Espacenet
JP 2025529142 A2025-09-047041P03956Espacenet
WO 2025177214 A12025-08-2814P03956Espacenet
US 12371689 B22025-07-297041P03956Espacenet
JP 2025517970 A2025-06-125455P03956Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DOXYCYCLINECHEMBL1200699Matrix metalloproteinase-1 inhibitorINHIBITORChEMBL
DOXYCYCLINE ANHYDROUSCHEMBL1433Matrix metalloproteinase-1 inhibitorINHIBITORChEMBL
DOXYCYCLINE CALCIUMCHEMBL2364574Matrix metalloproteinase-1 inhibitorINHIBITORChEMBL
DOXYCYCLINE HYCLATECHEMBL3989740Matrix metalloproteinase-1 inhibitorINHIBITORChEMBL
MARIMASTATCHEMBL279785Matrix metalloproteinase-1 inhibitorINHIBITORChEMBL
REBIMASTATCHEMBL76222Matrix metalloproteinase-1 inhibitorINHIBITORChEMBL

Trials 191

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07544251DOXYCYCLINEPHASE4ClinicalTrials.gov
NCT07488949DOXYCYCLINEClinicalTrials.gov
NCT07320001DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT07306234DOXYCYCLINEPHASE4ClinicalTrials.gov
NCT07180563DOXYCYCLINEPHASE1/PHASE2ClinicalTrials.gov
NCT07064278DOXYCYCLINEClinicalTrials.gov
NCT07027137DOXYCYCLINEClinicalTrials.gov
NCT06683638DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT06452394DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT06446245DOXYCYCLINEPHASE2ClinicalTrials.gov

NIH grants 7545

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant402,025NIH's project files
P30CA008748Cancer Center Support Grant292,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition192,025NIH's project files
P30CA068485Cancer Center Support Grant172,025NIH's project files
P30CA006973Regional Oncology Research Center162,025NIH's project files
P30CA023108Cancer Center Support Grant132,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award132,025NIH's project files
P30AG028716Duke Claude D. Pepper Older Americans Independence Center122,025NIH's project files
P30CA016087Cancer Center Support Grant122,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases122,025NIH's project files

Papers 25564

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826913PubTator, text miningPubMed
42820368PubTator, text miningPubMed
42811603PubTator, text miningPubMed
42808714PubTator, text miningPubMed
42806595PubTator, text miningPubMed
42804605PubTator, text miningPubMed
42798548PubTator, text miningPubMed
42795619PubTator, text miningPubMed
42795000PubTator, text miningPubMed
42794985PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license