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MMP2: matrix metallopeptidase 2

1 protein, 136 patents, 3 drugs, 13 trials, 13,695 NIH grants and 62,233 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMP2HGNC
Namematrix metallopeptidase 2HGNC
NCBI Gene ID4313NCBI Gene
HGNC IDHGNC:7166HGNC
EnsemblENSG00000087245NCBI Gene
AliasesCLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P0825372 kDa type IV collagenase66014Ensembl, GeneID, HGNCUniProt

Patents 136

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19432P08253Espacenet
US 12465641 B22025-11-11207P08253Espacenet
EP 4641201 A22025-10-29304P08253Espacenet
JP 2025147176 A2025-10-068790P08253Espacenet
JP 2025529142 A2025-09-047049P08253Espacenet
JP 2025526420 A2025-08-13207P08253Espacenet
US 12371689 B22025-07-297049P08253Espacenet
JP 2025517969 A2025-06-12304P08253Espacenet
JP 2025517970 A2025-06-12432P08253Espacenet
JP 2025032204 A2025-03-1131639P08253Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CTS-1027CHEMBL440498Matrix metalloproteinase-2 inhibitorINHIBITORChEMBL
MARIMASTATCHEMBL279785Matrix metalloproteinase-2 inhibitorINHIBITORChEMBL
REBIMASTATCHEMBL76222Matrix metalloproteinase-2 inhibitorINHIBITORChEMBL

Trials 13

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01273064CTS-1027PHASE22012-05-30ClinicalTrials.gov
NCT01051921CTS-1027PHASE22012-04-10ClinicalTrials.gov
NCT00925990CTS-1027PHASE22012-03-27ClinicalTrials.gov
NCT00570336CTS-1027PHASE2ClinicalTrials.gov
NCT00261391MARIMASTATPHASE1ClinicalTrials.gov
NCT00040755REBIMASTATPHASE2ClinicalTrials.gov
NCT00039104REBIMASTATPHASE2ClinicalTrials.gov
NCT00036621REBIMASTATPHASE2ClinicalTrials.gov
NCT00024024REBIMASTATPHASE1/PHASE2ClinicalTrials.gov
NCT00006229REBIMASTATPHASE2/PHASE3ClinicalTrials.gov

NIH grants 13695

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1192,025NIH's project files
P30CA008748Cancer Center Support Grant392,025NIH's project files
P30CA016058Cancer Center Support Grant352,025NIH's project files
P30CA006973Regional Oncology Research Center302,025NIH's project files
P30CA068485Cancer Center Support Grant292,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support282,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT272,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award222,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant212,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant192,025NIH's project files

Papers 62233

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826092PubTator, text miningPubMed
42825327PubTator, text miningPubMed
42817098PubTator, text miningPubMed
42815331PubTator, text miningPubMed
42812068PubTator, text miningPubMed
42809506PubTator, text miningPubMed
42801549PubTator, text miningPubMed
42800415PubTator, text miningPubMed
42798633PubTator, text miningPubMed
42795619PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license