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MMP7: matrix metallopeptidase 7

1 protein, 166 patents, 5 drugs, 186 trials, 4,688 NIH grants and 11,446 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMP7HGNC
Namematrix metallopeptidase 7HGNC
NCBI Gene ID4316NCBI Gene
HGNC IDHGNC:7174HGNC
EnsemblENSG00000137673NCBI Gene
AliasesMMP-7, MPSL1, PUMP-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P09237Matrilysin26716Ensembl, GeneID, HGNCUniProt

Patents 166

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777129 A12026-07-2261P09237Espacenet
JP 2026000906 A2026-01-06113P09237Espacenet
JP 2025174757 A2025-11-282P09237Espacenet
WO 2025239413 A2025-11-202P09237Espacenet
EP 4650780 A22025-11-191788P09237Espacenet
WO 2025219999 A12025-10-231P09237Espacenet
JP 2025147176 A2025-10-068813P09237Espacenet
JP 2025529142 A2025-09-047056P09237Espacenet
US 12396991 B22025-08-2660P09237Espacenet
US 12371689 B22025-07-297056P09237Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DOXYCYCLINECHEMBL1200699Matrix metalloproteinase 7 inhibitorINHIBITORChEMBL
DOXYCYCLINE ANHYDROUSCHEMBL1433Matrix metalloproteinase 7 inhibitorINHIBITORChEMBL
DOXYCYCLINE CALCIUMCHEMBL2364574Matrix metalloproteinase 7 inhibitorINHIBITORChEMBL
DOXYCYCLINE HYCLATECHEMBL3989740Matrix metalloproteinase 7 inhibitorINHIBITORChEMBL
MARIMASTATCHEMBL279785Matrix metalloproteinase 7 inhibitorINHIBITORChEMBL

Trials 186

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07544251DOXYCYCLINEPHASE4ClinicalTrials.gov
NCT07488949DOXYCYCLINEClinicalTrials.gov
NCT07320001DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT07306234DOXYCYCLINEPHASE4ClinicalTrials.gov
NCT07180563DOXYCYCLINEPHASE1/PHASE2ClinicalTrials.gov
NCT07064278DOXYCYCLINEClinicalTrials.gov
NCT07027137DOXYCYCLINEClinicalTrials.gov
NCT06683638DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT06452394DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT06446245DOXYCYCLINEPHASE2ClinicalTrials.gov

NIH grants 4688

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant382,025NIH's project files
P30CA068485Cancer Center Support Grant382,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases302,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant152,025NIH's project files
P30CA008748Cancer Center Support Grant142,025NIH's project files
T32CA009592Microenvironmental Influences in Cancer122,025NIH's project files
P30CA006973Regional Oncology Research Center102,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)102,025NIH's project files
P30CA047904Cancer Center Support Grant102,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease102,025NIH's project files

Papers 11446

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42756821PubTator, text miningPubMed
42748406PubTator, text miningPubMed
42704313PubTator, text miningPubMed
42701762PubTator, text miningPubMed
42651647PubTator, text miningPubMed
42644235PubTator, text miningPubMed
42644042PubTator, text miningPubMed
42641423PubTator, text miningPubMed
42614068PubTator, text miningPubMed
42613631PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license