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MMP8: matrix metallopeptidase 8

1 protein, 98 patents, 6 drugs, 191 trials, 2,865 NIH grants and 7,550 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMP8HGNC
Namematrix metallopeptidase 8HGNC
NCBI Gene ID4317NCBI Gene
HGNC IDHGNC:7175HGNC
EnsemblENSG00000118113NCBI Gene
AliasesCLG1, HNC, MMP-8, PMNL-CLNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P22894Neutrophil collagenase46725Ensembl, GeneID, HGNCUniProt

Patents 98

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19923P22894Espacenet
EP 4641201 A22025-10-29646P22894Espacenet
JP 2025147176 A2025-10-068814P22894Espacenet
JP 2025529142 A2025-09-047057P22894Espacenet
US 12392775 B22025-08-1918P22894Espacenet
US 12371689 B22025-07-297057P22894Espacenet
JP 2025517969 A2025-06-12646P22894Espacenet
JP 2025517970 A2025-06-12923P22894Espacenet
JP 2025028160 A2025-02-288814P22894Espacenet
JP 2025013347 A2025-01-24131P22894Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CTS-1027CHEMBL440498Matrix metalloproteinase 8 inhibitorINHIBITORChEMBL
DOXYCYCLINECHEMBL1200699Matrix metalloproteinase 8 inhibitorINHIBITORChEMBL
DOXYCYCLINE ANHYDROUSCHEMBL1433Matrix metalloproteinase 8 inhibitorINHIBITORChEMBL
DOXYCYCLINE CALCIUMCHEMBL2364574Matrix metalloproteinase 8 inhibitorINHIBITORChEMBL
DOXYCYCLINE HYCLATECHEMBL3989740Matrix metalloproteinase 8 inhibitorINHIBITORChEMBL
REBIMASTATCHEMBL76222Matrix metalloproteinase 8 inhibitorINHIBITORChEMBL

Trials 191

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07544251DOXYCYCLINEPHASE4ClinicalTrials.gov
NCT07488949DOXYCYCLINEClinicalTrials.gov
NCT07320001DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT07306234DOXYCYCLINEPHASE4ClinicalTrials.gov
NCT07180563DOXYCYCLINEPHASE1/PHASE2ClinicalTrials.gov
NCT07064278DOXYCYCLINEClinicalTrials.gov
NCT07027137DOXYCYCLINEClinicalTrials.gov
NCT06683638DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT06452394DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT06446245DOXYCYCLINEPHASE2ClinicalTrials.gov

NIH grants 2865

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition562,025NIH's project files
P30CA013148Comprehensive Cancer Center Support Grant82,025NIH's project files
P30CA016672Cancer Center Support Grant82,025NIH's project files
ZIAAI001065India International Center for Excellence in Research72,025NIH's project files
K12HD047349Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP)62,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease62,025NIH's project files
R01HL076246Chemokines in healing myocardial infarction62,025NIH's project files
R01HL085440Resolution of inflammation in healing myocardial infarcts62,025NIH's project files
T32GM008478Host Response to Trauma Research Training Program62,025NIH's project files
T32GM008721Molecular Biology in Burns and Trauma62,025NIH's project files

Papers 7550

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42791914PubTator, text miningPubMed
42783158PubTator, text miningPubMed
42772841PubTator, text miningPubMed
42772839PubTator, text miningPubMed
42769250PubTator, text miningPubMed
42757340PubTator, text miningPubMed
42729716PubTator, text miningPubMed
42709166PubTator, text miningPubMed
42698451PubTator, text miningPubMed
42689110PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license