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MMP9: matrix metallopeptidase 9

1 protein, 135 patents, 5 drugs, 28 trials, 18,954 NIH grants and 86,946 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMP9HGNC
Namematrix metallopeptidase 9HGNC
NCBI Gene ID4318NCBI Gene
HGNC IDHGNC:7176HGNC
EnsemblENSG00000100985NCBI Gene
AliasesCLG4B, GELB, MANDP2, MMP-9NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14780Matrix metalloproteinase-970729Ensembl, GeneID, HGNCUniProt

Patents 135

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12560619 B22026-02-2438P14780Espacenet
EP 4650780 A22025-11-199089P14780Espacenet
US 12465641 B22025-11-11209P14780Espacenet
EP 4640849 A22025-10-291360P14780Espacenet
EP 4641201 A22025-10-299359P14780Espacenet
JP 2025533510 A2025-10-072P14780Espacenet
JP 2025147176 A2025-10-068820P14780Espacenet
JP 2025532094 A2025-09-296P14780Espacenet
WO 2025186446 A12025-09-1237P14780Espacenet
EP 4613860 A12025-09-1037P14780Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANDECALIXIMABCHEMBL3833374Matrix metalloproteinase 9 inhibitorINHIBITORChEMBL
AZD-1236CHEMBL4297352Matrix metalloproteinase 9 inhibitorINHIBITORChEMBL
CTS-1027CHEMBL440498Matrix metalloproteinase 9 inhibitorINHIBITORChEMBL
MARIMASTATCHEMBL279785Matrix metalloproteinase 9 inhibitorINHIBITORChEMBL
REBIMASTATCHEMBL76222Matrix metalloproteinase 9 inhibitorINHIBITORChEMBL

Trials 28

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06508021ANDECALIXIMABPHASE2/PHASE3ClinicalTrials.gov
NCT02864381ANDECALIXIMABPHASE22020-09-18ClinicalTrials.gov
NCT02862574ANDECALIXIMABPHASE22018-06-27ClinicalTrials.gov
NCT02862535ANDECALIXIMABPHASE12020-12-24ClinicalTrials.gov
NCT02759562ANDECALIXIMABPHASE22018-07-05ClinicalTrials.gov
NCT02545504ANDECALIXIMABPHASE32020-04-28ClinicalTrials.gov
NCT02520284ANDECALIXIMABPHASE2/PHASE32019-04-10ClinicalTrials.gov
NCT02405442ANDECALIXIMABPHASE22019-03-28ClinicalTrials.gov
NCT02176876ANDECALIXIMABPHASE1ClinicalTrials.gov
NCT02077465ANDECALIXIMABPHASE12020-08-13ClinicalTrials.gov

NIH grants 18954

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2152,025NIH's project files
P30CA008748Cancer Center Support Grant662,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award482,025NIH's project files
P30CA006973Regional Oncology Research Center442,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant392,025NIH's project files
P30CA016058Cancer Center Support Grant392,025NIH's project files
P30CA068485Cancer Center Support Grant372,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition362,025NIH's project files
P30EY014801Miami Center for Vision Research352,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support342,025NIH's project files

Papers 86946

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825327PubTator, text miningPubMed
42823991PubTator, text miningPubMed
42823178PubTator, text miningPubMed
42817098PubTator, text miningPubMed
42816096PubTator, text miningPubMed
42815330PubTator, text miningPubMed
42815207PubTator, text miningPubMed
42813677PubTator, text miningPubMed
42812068PubTator, text miningPubMed
42811434PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license