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Gene · 432

ASGR1: asialoglycoprotein receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ASGR1: asialoglycoprotein receptor 1. Genes, record 432. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/432

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Gene

Symbol
ASGR1
HGNC
Name
asialoglycoprotein receptor 1
HGNC
NCBI Gene ID
432
NCBI Gene
HGNC ID
HGNC:742
HGNC
Ensembl
ENSG00000141505
NCBI Gene
Aliases
ASGPR, ASGPR1, CLEC4H1, HL-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07306Asialoglycoprotein receptor 12918Ensembl, GeneID, HGNC

Source UniProt

Patents95

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4727595 A22026-04-2229P07306Espacenet
EP 4705462 A22026-03-1180P07306Espacenet
JP 2026016543 A2026-02-031P07306Espacenet
JP 2026004568 A2026-01-1437938P07306Espacenet
EP 4650780 A22025-11-192701P07306Espacenet
EP 4640849 A22025-10-29332P07306Espacenet
EP 4641201 A22025-10-292289P07306Espacenet
JP 2025535145 A2025-10-221P07306Espacenet
JP 2025519096 A2025-06-24332P07306Espacenet
JP 2025517969 A2025-06-122289P07306Espacenet

1 to 10 of 95

See all 95 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
VUPANORSENCHEMBL4298197Asialoglycoprotein receptor 1 binding agentBINDING AGENTChEMBL
VUPANORSEN SODIUMCHEMBL4298198Asialoglycoprotein receptor 1 binding agentBINDING AGENTChEMBL

Trials6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04516291VUPANORSENPHASE22022-10-04ClinicalTrials.gov
NCT04459767VUPANORSENPHASE1ClinicalTrials.gov
NCT03514420VUPANORSENPHASE22021-02-16ClinicalTrials.gov
NCT03455777VUPANORSENPHASE2ClinicalTrials.gov
NCT03371355VUPANORSENPHASE22021-02-01ClinicalTrials.gov
NCT03360747VUPANORSENPHASE22021-01-07ClinicalTrials.gov

NIH grants1,038

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleASGR1 papersNewest fiscal year
R01HL089224Carbohydrate-Mediated Platelet Clearance82025
R01DK078244Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes72025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease52025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology52025
P30CA008748Cancer Center Support Grant42025
P30CA013330Cancer Center Support Grant42025
P30CA045508CSHL Cancer Center Support Grant42025
P30CA093373Cancer Center Support Grant P3042025
R01CA255727Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma42025
P01CA013106Targeting Transcription and Splicing in Cancer32025

1 to 10 of 1,038Source NIH's project files

See all 1,038 nih grants

Papers2,727

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A hepatic-targeting NIR fluorescent probe simultaneously unlocked by BChE and high viscosity in diabetes mellitus.Spectrochim Acta A Mol Biomol Spectrosc202742785018PubTator, text miningPubMed
Genetically engineered porcine liver: a new era in transplantation.Int J Surg202642808109PubTator, text miningPubMed
Re: ASGR1 Deficiency Promotes Liver Fibrosis by Enhancing Pro-Inflammatory Arachidonic Acid Metabolism and ALP Secretion.Immun Inflamm Dis202642806895PubTator, text miningPubMed
Targeted dual degradation of GPC-3 and VEGFR with multivalent DNA nanoflower-based LYTACs for hepatocellular carcinoma therapy.J Control Release202642777829PubTator, text miningPubMed
Hyperbaric Oxygen Treatment Enhances Definitive Endoderm Differentiation and Hepatic Maturation of Human-Induced Pluripotent Stem Cells in Association with mTORC2-Dependent AKT Phosphorylation.Int J Stem Cells202642750199PubTator, text miningPubMed
Ligand Arm Length Governs Geometry, Spin State, and Reactivity in Unsymmetrical β-Diketiminato Nickel(II) and Nickel(I) Complexes.Inorg Chem202642734380PubTator, text miningPubMed
Advances in galactose-based small-molecule hepatocyte-targeting probes for detecting biomarkers in hepatocellular carcinoma.Front Chem202642694819PubTator, text miningPubMed
A ternary nanocomplex for hepatocyte-targeted gene delivery and treatment of metabolic dysfunction-associated steatotic liver disease.RSC Adv202642626613PubTator, text miningPubMed
DNA methylation informs adult cardiovascular risk and prevention for low birthweight individuals.J Glob Health202642596884PubTator, text miningPubMed
Decoding the Complexity of Hepatocellular Carcinoma: Clinical Challenges and Targeting HuR as a Novel Therapeutic Strategy.Livers202642583674PubTator, text miningPubMed

1 to 10 of 2,727

See all 2,727 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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