ConductScience.org, home

Library / Genes

MMP12: matrix metallopeptidase 12

1 protein, 92 patents, 3 drugs, 11 trials, 3,008 NIH grants and 5,865 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMP12HGNC
Namematrix metallopeptidase 12HGNC
NCBI Gene ID4321NCBI Gene
HGNC IDHGNC:7158HGNC
EnsemblENSG00000262406NCBI Gene
AliasesHME, ME, MME, MMP-12NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P39900Macrophage metalloelastase47086Ensembl, GeneID, HGNCUniProt

Patents 92

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777129 A12026-07-2267P39900Espacenet
EP 4650780 A22025-11-1917291P39900Espacenet
EP 4641201 A22025-10-2921339P39900Espacenet
JP 2025533510 A2025-10-074P39900Espacenet
JP 2025147176 A2025-10-068768P39900Espacenet
JP 2025529142 A2025-09-047044P39900Espacenet
US 12371689 B22025-07-297044P39900Espacenet
JP 2025517969 A2025-06-1221339P39900Espacenet
JP 2025517970 A2025-06-1217291P39900Espacenet
WO 2025081160 A12025-04-1749P39900Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-1236CHEMBL4297352Matrix metalloproteinase 12 inhibitorINHIBITORChEMBL
CTS-1027CHEMBL440498Matrix metalloproteinase 12 inhibitorINHIBITORChEMBL
MARIMASTATCHEMBL279785Matrix metalloproteinase 12 inhibitorINHIBITORChEMBL

Trials 11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01273064CTS-1027PHASE22012-05-30ClinicalTrials.gov
NCT01051921CTS-1027PHASE22012-04-10ClinicalTrials.gov
NCT00925990CTS-1027PHASE22012-03-27ClinicalTrials.gov
NCT00812045AZD-1236PHASE2ClinicalTrials.gov
NCT00758706AZD-1236PHASE22015-04-16ClinicalTrials.gov
NCT00758459AZD-1236PHASE22011-08-19ClinicalTrials.gov
NCT00570336CTS-1027PHASE2ClinicalTrials.gov
NCT00261391MARIMASTATPHASE1ClinicalTrials.gov
NCT00003011MARIMASTATPHASE3ClinicalTrials.gov
NCT00003010MARIMASTATPHASE3ClinicalTrials.gov

NIH grants 3008

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UL1TR001863Yale Clinical and Translational Science Award92,025NIH's project files
P30CA008748Cancer Center Support Grant62,025NIH's project files
P30CA016087Cancer Center Support Grant62,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
P30CA068485Cancer Center Support Grant62,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease62,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE62,025NIH's project files
U54GM115428Mississippi Center for Clinical and Translational Research62,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA52,025NIH's project files
P30DK017047Diabetes Research Center52,025NIH's project files

Papers 5865

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42795000PubTator, text miningPubMed
42762842PubTator, text miningPubMed
42744590PubTator, text miningPubMed
42734518PubTator, text miningPubMed
42716194PubTator, text miningPubMed
42691620PubTator, text miningPubMed
42688676PubTator, text miningPubMed
42679163PubTator, text miningPubMed
42669837PubTator, text miningPubMed
42663337PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license