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MMP13: matrix metallopeptidase 13

1 protein, 91 patents, 7 drugs, 192 trials, 4,346 NIH grants and 15,631 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMP13HGNC
Namematrix metallopeptidase 13HGNC
NCBI Gene ID4322NCBI Gene
HGNC IDHGNC:7159HGNC
EnsemblENSG00000137745NCBI Gene
AliasesCLG3, MANDP1, MDST, MMP-13NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P45452Collagenase 347149Ensembl, GeneID, HGNCUniProt

Patents 91

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026138951 A2026-08-317P45452Espacenet
EP 4729612 A22026-04-2266P45452Espacenet
JP 2026068735 A2026-04-22115P45452Espacenet
EP 4678235 A22026-01-14115P45452Espacenet
EP 4650780 A22025-11-191793P45452Espacenet
JP 2025147176 A2025-10-068769P45452Espacenet
JP 2025517970 A2025-06-121793P45452Espacenet
JP 2025084910 A2025-06-0326P45452Espacenet
KR 1020250036278 A2025-03-13115P45452Espacenet
JP 2025028160 A2025-02-288769P45452Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APRATASTATCHEMBL206815Matrix metalloproteinase 13 inhibitorINHIBITORChEMBL
CTS-1027CHEMBL440498Matrix metalloproteinase 13 inhibitorINHIBITORChEMBL
DOXYCYCLINECHEMBL1200699Matrix metalloproteinase 13 inhibitorINHIBITORChEMBL
DOXYCYCLINE ANHYDROUSCHEMBL1433Matrix metalloproteinase 13 inhibitorINHIBITORChEMBL
DOXYCYCLINE CALCIUMCHEMBL2364574Matrix metalloproteinase 13 inhibitorINHIBITORChEMBL
DOXYCYCLINE HYCLATECHEMBL3989740Matrix metalloproteinase 13 inhibitorINHIBITORChEMBL
REBIMASTATCHEMBL76222Matrix metalloproteinase 13 inhibitorINHIBITORChEMBL

Trials 192

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07544251DOXYCYCLINEPHASE4ClinicalTrials.gov
NCT07488949DOXYCYCLINEClinicalTrials.gov
NCT07320001DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT07306234DOXYCYCLINEPHASE4ClinicalTrials.gov
NCT07180563DOXYCYCLINEPHASE1/PHASE2ClinicalTrials.gov
NCT07064278DOXYCYCLINEClinicalTrials.gov
NCT07027137DOXYCYCLINEClinicalTrials.gov
NCT06683638DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT06452394DOXYCYCLINEPHASE2ClinicalTrials.gov
NCT06446245DOXYCYCLINEPHASE2ClinicalTrials.gov

NIH grants 4346

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK047420Nuclear Events in PTHR1 Action on Bone272,025NIH's project files
R01AG044034Oxidative Stress and the Development of Osteoarthritis212,025NIH's project files
P30CA016672Cancer Center Support Grant142,025NIH's project files
P30CA068485Cancer Center Support Grant122,025NIH's project files
P30AG028716Duke Claude D. Pepper Older Americans Independence Center112,025NIH's project files
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE102,025NIH's project files
P30AG021332Wake Forest Claude D. Pepper OAIC - Renewal92,025NIH's project files
P30AG024827Pittsburgh Older Americans Independence Center92,025NIH's project files
P30CA008748Cancer Center Support Grant82,025NIH's project files
P30AR069619Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)72,025NIH's project files

Papers 15631

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823181PubTator, text miningPubMed
42808173PubTator, text miningPubMed
42803954PubTator, text miningPubMed
42801603PubTator, text miningPubMed
42792769PubTator, text miningPubMed
42789005PubTator, text miningPubMed
42787916PubTator, text miningPubMed
42778011PubTator, text miningPubMed
42772837PubTator, text miningPubMed
42750492PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license