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MMP14: matrix metallopeptidase 14

1 protein, 98 patents, 2 drugs, 9 trials, 4,682 NIH grants and 11,145 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMMP14HGNC
Namematrix metallopeptidase 14HGNC
NCBI Gene ID4323NCBI Gene
HGNC IDHGNC:7160HGNC
EnsemblENSG00000157227NCBI Gene
AliasesMMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P50281Matrix metalloproteinase-1458212Ensembl, GeneID, HGNCUniProt

Patents 98

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777129 A12026-07-2270P50281Espacenet
EP 4650780 A22025-11-194542P50281Espacenet
EP 4640849 A22025-10-29607P50281Espacenet
EP 4641201 A22025-10-294098P50281Espacenet
JP 2025161810 A2025-10-2423P50281Espacenet
JP 2025147176 A2025-10-068773P50281Espacenet
JP 2025529142 A2025-09-042662P50281Espacenet
JP 2025529142 A2025-09-047046P50281Espacenet
US 12371689 B22025-07-292662P50281Espacenet
US 12371689 B22025-07-297046P50281Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CTS-1027CHEMBL440498Matrix metalloproteinase 14 inhibitorINHIBITORChEMBL
REBIMASTATCHEMBL76222Matrix metalloproteinase 14 inhibitorINHIBITORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01273064CTS-1027PHASE22012-05-30ClinicalTrials.gov
NCT01051921CTS-1027PHASE22012-04-10ClinicalTrials.gov
NCT00925990CTS-1027PHASE22012-03-27ClinicalTrials.gov
NCT00570336CTS-1027PHASE2ClinicalTrials.gov
NCT00040755REBIMASTATPHASE2ClinicalTrials.gov
NCT00039104REBIMASTATPHASE2ClinicalTrials.gov
NCT00036621REBIMASTATPHASE2ClinicalTrials.gov
NCT00024024REBIMASTATPHASE1/PHASE2ClinicalTrials.gov
NCT00006229REBIMASTATPHASE2/PHASE3ClinicalTrials.gov

NIH grants 4682

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant232,025NIH's project files
P30EY001792P30 Core Grant for Vision Research192,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase152,025NIH's project files
P30EY010572Ophthalmology Core Facility152,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT142,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)142,025NIH's project files
P30CA068485Cancer Center Support Grant132,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant122,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30EY005722Center Core Grant for Vision Research112,025NIH's project files

Papers 11145

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807931PubTator, text miningPubMed
42783079PubTator, text miningPubMed
42774130PubTator, text miningPubMed
42773217PubTator, text miningPubMed
42772842PubTator, text miningPubMed
42772840PubTator, text miningPubMed
42743222PubTator, text miningPubMed
42741420PubTator, text miningPubMed
42739515PubTator, text miningPubMed
42738649PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license