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Gene · 4325

MMP16: matrix metallopeptidase 16

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MMP16: matrix metallopeptidase 16. Genes, record 4325. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4325

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Gene

Symbol
MMP16
HGNC
Name
matrix metallopeptidase 16
HGNC
NCBI Gene ID
4325
NCBI Gene
HGNC ID
HGNC:7162
HGNC
Ensembl
ENSG00000156103
NCBI Gene
Aliases
C8orf57, DKFZp761D112, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51512Matrix metalloproteinase-166071Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193295P51512Espacenet
EP 4641201 A22025-10-292871P51512Espacenet
JP 2025529142 A2025-09-042664P51512Espacenet
US 12371689 B22025-07-292664P51512Espacenet
JP 2025517969 A2025-06-122871P51512Espacenet
JP 2025517970 A2025-06-123295P51512Espacenet
JP 2025062601 A2025-04-1475P51512Espacenet
JP 2025032204 A2025-03-1131635P51512Espacenet
EP 4461818 A22024-11-1331635P51512Espacenet
JP 2023058610 A2023-04-2531635P51512Espacenet

1 to 10 of 53

See all 53 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,066

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMMP16 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30CA016087Cancer Center Support Grant42025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant42025
P50CA116201Mayo Clinic Breast Cancer SPORE42025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)42025
P30CA030199Cancer Center Support Grant (CCSG)32025
P30CA072720Cancer Center Support Grant32025
P30EY010572Ophthalmology Core Facility32025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition32025
P30CA008748Cancer Center Support Grant22025

1 to 10 of 1,066Source NIH's project files

See all 1,066 nih grants

Papers1,529

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
An Exploratory Study of Vitamin D and Matrix Metalloproteinase and Their Regulators in Polyendocrine Metabolic Ovarian Syndrome.Pharmaceuticals (Basel)202642653642PubTator, text miningPubMed
From sebocytes to skin engineering human sebaceous organoids within a reconstructed dermal matrix.Front Toxicol202642598348PubTator, text miningPubMed
An integrative analysis of UFMylation-related genes reveals a prognostic signature and identifies GDF7 as a novel therapeutic target in gastric cancer.Front Oncol202642577178PubTator, text miningPubMed
Meta-Analysis of Genome-Wide Association Studies of Doxorubicin-Induced Arrhythmia Identifies MMP16 and KCTD15 as Risk Loci.Circ Genom Precis Med202642522562PubTator, text miningPubMed
Structure-Guided Discovery of a Nonpeptidic MT5-MMP Inhibitor.ACS Med Chem Lett202642305194PubTator, text miningPubMed
Advances in Extracellular Matrix Metalloproteinases: Implications for Renal Cell Carcinoma Pathophysiology, Diagnostics, and Therapeutics.Medicines (Basel)202641893368PubTator, text miningPubMed
Proteome-wide Mendelian randomization and colocalization analyses identify potential biomarkers for schizophrenia.Front Psychiatry202641836659PubTator, text miningPubMed
Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis.Dialogues Clin Neurosci202641797490PubTator, text miningPubMed
Pilot study: predicting the interplay between FOXO1 and its downstream long non-coding RNAs in HCC.Front Oncol202641777650PubTator, text miningPubMed
Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex.bioRxiv202641757081PubTator, text miningPubMed

1 to 10 of 1,529

See all 1,529 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4325

GET https://conductscience.org/api/genes/v1/4325/patents?page=2