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Gene · 434

ASIP: agouti signaling protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ASIP: agouti signaling protein. Genes, record 434. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/434

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Gene

Symbol
ASIP
HGNC
Name
agouti signaling protein
HGNC
NCBI Gene ID
434
NCBI Gene
HGNC ID
HGNC:745
HGNC
Ensembl
ENSG00000101440
NCBI Gene
Aliases
AGSW, AGTI, AGTIL, ASP, SHEP9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42127Agouti-signaling protein1324Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436943P42127Espacenet
EP 4650780 A22025-11-199552P42127Espacenet
JP 2025147176 A2025-10-061203P42127Espacenet
JP 2025147176 A2025-10-061204P42127Espacenet
JP 2025529142 A2025-09-045537P42127Espacenet
US 12371689 B22025-07-295537P42127Espacenet
JP 2025517970 A2025-06-129552P42127Espacenet
JP 2025062604 A2025-04-143643P42127Espacenet
JP 2025062604 A2025-04-143644P42127Espacenet
JP 2025028160 A2025-02-281203P42127Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants433

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleASIP papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA016086Cancer Center Support Grant72025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant62025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
T32CA165990Interdisciplinary Research Training in Cancer Biology62025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment42025
R01CA241623The Role of Genetic Risk Factors in Keratinocyte Carcinoma Susceptibility42025
ZIACP004410Family Studies42025
K24AR069760Patient oriented research and mentoring program in dermatologic diseases32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025

1 to 10 of 433Source NIH's project files

See all 433 nih grants

Papers654

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular and Evolutionary Basis of Avian Plumage Colour.Biology (Basel)202642510724PubTator, text miningPubMed
ASIP Variants in Livestock: It's Not Black and White.Anim Genet202642237701PubTator, text miningPubMed
Agouti signalling protein and triglyceride-glucose index in early pregnancy with gestational diabetes: a prospective cohort study.J Obstet Gynaecol202642101196PubTator, text miningPubMed
The ASIP Cys-98 Allele Is Not Associated With Black Coat Color in Water Buffaloes.Anim Genet202641964159PubTator, text miningPubMed
Structural Coloration and Carotenoids Together Create the Vibrant Colors of Peafowl Feathers.Animals (Basel)202641897879PubTator, text miningPubMed
Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling.Brain Behav202641601423PubTator, text miningPubMed
Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study.Pharmaceuticals (Basel)202641599712PubTator, text miningPubMed
Molecular effects of transposable element sequences in mammalian cells.Genome Biol202541299541PubTator, text miningPubMed
Genetic imputation of transcriptome and proteome illuminates novel therapeutic targets of cutaneous melanoma.Brief Bioinform202541148223PubTator, text miningPubMed
A mosaic of modular variation at a single gene underpins convergent plumage coloration.Science202541100596PubTator, text miningPubMed

1 to 10 of 654

See all 654 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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