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Gene · 435

ASL: argininosuccinate lyase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ASL: argininosuccinate lyase. Genes, record 435. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/435

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Gene

Symbol
ASL
HGNC
Name
argininosuccinate lyase
HGNC
NCBI Gene ID
435
NCBI Gene
HGNC ID
HGNC:746
HGNC
Ensembl
ENSG00000126522
NCBI Gene
Aliases
ASAL, ASLD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P04424Argininosuccinate lyase4642Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-2189P04424Espacenet
WO 2025255199 A12025-12-1128P04424Espacenet
JP 2025169942 A2025-11-14825P04424Espacenet
JP 2025169942 A2025-11-14828P04424Espacenet
EP 4555087 A22025-05-2158P04424Espacenet
JP 2025062604 A2025-04-146231P04424Espacenet
JP 2025062604 A2025-04-146235P04424Espacenet
JP 2024519469 A2024-05-1469P04424Espacenet
KR 1020240001708 A2024-01-0358P04424Espacenet
US 11684584 B22023-06-272P04424Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants904

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleASL papersNewest fiscal year
T32GM007526Medical Genetics Research Fellowship Program102025
P50HD103555Baylor College of Medicine Intellectual and Developmental Disabilities Research Center72025
P30CA016672Cancer Center Support Grant52025
P30DK056338Texas Medical Center Digestive Diseases Center52025
P30CA008748Cancer Center Support Grant42025
P30CA093373Cancer Center Support Grant P3042025
R01HL060190Metabolic reprogramming of smooth muscle cells in pulmonary hypertension42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
UL1TR001863Yale Clinical and Translational Science Award32025
ZIAHG200381Metabolism, infection and immunity in inborn errors of mitochondrial metabolism32025

1 to 10 of 904Source NIH's project files

See all 904 nih grants

Papers1,794

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical, Biochemical, and Molecular Analyses of Three Patients with Urea Cycle Disorders in China.Ann Clin Lab Sci202642790946PubTator, text miningPubMed
An Exopolysaccharide from Lactiplantibacillus plantarum ZGS521 Alleviates Colitis via Gut Microbiota Modulation and Enhanced Arginine Biosynthesis.J Agric Food Chem202642677610PubTator, text miningPubMed
A Metabo-Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21-Arginine Axis.Adv Mater202642554227PubTator, text miningPubMed
Multi-omics analysis of arginine metabolism in ovarian cancer: A prognostic signature and GTF2F2-driven stromal remodeling.Transl Oncol202642442222PubTator, text miningPubMed
SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function.bioRxiv202642427712PubTator, text miningPubMed
Integrative bulk and single-cell analyses implicate ASL in MIF-associated myeloid programs in glioblastoma.Funct Integr Genomics202642420626PubTator, text miningPubMed
Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts.Cell Rep202642276069PubTator, text miningPubMed
Nitrogen Isotope Effects in Urea Metabolism: From Biochemistry to 15N Natural Abundance in Cancer.Int J Mol Sci202642074106PubTator, text miningPubMed
Arginine dependency in omental metastasis of epithelial ovarian cancer reveals a therapeutic vulnerability.Cell Death Dis202641876452PubTator, text miningPubMed
Adaptive crosstalk between polyamine metabolism, translation, and autophagy sustains energy homeostasis in mammals during starvation: a scoping review.Amino Acids202641874700PubTator, text miningPubMed

1 to 10 of 1,794

See all 1,794 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/435

GET https://conductscience.org/api/genes/v1/435/patents?page=2