Gene · 435
ASL: argininosuccinate lyase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ASL: argininosuccinate lyase. Genes, record 435. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/435
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P04424 | Argininosuccinate lyase | 464 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 89 | P04424 | Espacenet |
| WO 2025255199 A1 | 2025-12-11 | 28 | P04424 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 825 | P04424 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 828 | P04424 | Espacenet |
| EP 4555087 A2 | 2025-05-21 | 58 | P04424 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 6231 | P04424 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 6235 | P04424 | Espacenet |
| JP 2024519469 A | 2024-05-14 | 69 | P04424 | Espacenet |
| KR 1020240001708 A | 2024-01-03 | 58 | P04424 | Espacenet |
| US 11684584 B2 | 2023-06-27 | 2 | P04424 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants904
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ASL papers | Newest fiscal year |
|---|---|---|---|
| T32GM007526 | Medical Genetics Research Fellowship Program | 10 | 2025 |
| P50HD103555 | Baylor College of Medicine Intellectual and Developmental Disabilities Research Center | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 4 | 2025 |
| R01HL060190 | Metabolic reprogramming of smooth muscle cells in pulmonary hypertension | 4 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| ZIAHG200381 | Metabolism, infection and immunity in inborn errors of mitochondrial metabolism | 3 | 2025 |
1 to 10 of 904Source NIH's project files
See all 904 nih grantsPapers1,794
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical, Biochemical, and Molecular Analyses of Three Patients with Urea Cycle Disorders in China. | Ann Clin Lab Sci | 2026 | 42790946 | PubTator, text mining | PubMed |
| An Exopolysaccharide from Lactiplantibacillus plantarum ZGS521 Alleviates Colitis via Gut Microbiota Modulation and Enhanced Arginine Biosynthesis. | J Agric Food Chem | 2026 | 42677610 | PubTator, text mining | PubMed |
| A Metabo-Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21-Arginine Axis. | Adv Mater | 2026 | 42554227 | PubTator, text mining | PubMed |
| Multi-omics analysis of arginine metabolism in ovarian cancer: A prognostic signature and GTF2F2-driven stromal remodeling. | Transl Oncol | 2026 | 42442222 | PubTator, text mining | PubMed |
| SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function. | bioRxiv | 2026 | 42427712 | PubTator, text mining | PubMed |
| Integrative bulk and single-cell analyses implicate ASL in MIF-associated myeloid programs in glioblastoma. | Funct Integr Genomics | 2026 | 42420626 | PubTator, text mining | PubMed |
| Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts. | Cell Rep | 2026 | 42276069 | PubTator, text mining | PubMed |
| Nitrogen Isotope Effects in Urea Metabolism: From Biochemistry to 15N Natural Abundance in Cancer. | Int J Mol Sci | 2026 | 42074106 | PubTator, text mining | PubMed |
| Arginine dependency in omental metastasis of epithelial ovarian cancer reveals a therapeutic vulnerability. | Cell Death Dis | 2026 | 41876452 | PubTator, text mining | PubMed |
| Adaptive crosstalk between polyamine metabolism, translation, and autophagy sustains energy homeostasis in mammals during starvation: a scoping review. | Amino Acids | 2026 | 41874700 | PubTator, text mining | PubMed |
1 to 10 of 1,794
See all 1,794 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/435
GET https://conductscience.org/api/genes/v1/435/patents?page=2