Gene · 4350
MPG: N-methylpurine DNA glycosylase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MPG: N-methylpurine DNA glycosylase. Genes, record 4350. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4350
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P29372 | DNA-3-methyladenine glycosylase | 298 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12624353 B2 | 2026-05-12 | 3938 | P29372 | Espacenet |
| US 12624354 B2 | 2026-05-12 | 3938 | P29372 | Espacenet |
| US 12570972 B2 | 2026-03-10 | 3938 | P29372 | Espacenet |
| US 12509680 B2 | 2025-12-30 | 3938 | P29372 | Espacenet |
| US 12281303 B2 | 2025-04-22 | 3938 | P29372 | Espacenet |
| EP 4522738 A1 | 2025-03-19 | 1 | P29372 | Espacenet |
| JP 2024542790 A | 2024-11-15 | 200 | P29372 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7362 | P29372 | Espacenet |
| JP 2024530487 A | 2024-08-21 | 134 | P29372 | Espacenet |
| US 12043827 B2 | 2024-07-23 | 84 | P29372 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,333
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MPG papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 16 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 13 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 9 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 7 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 7 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 7 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 6 | 2025 |
| P42ES027707 | The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous Chemicals | 6 | 2025 |
| R35ES031638 | Watching cooperative interactions between base and nucleotide excision repair proteins | 6 | 2025 |
| T32ES007028 | Training Program in Environmental Toxicology | 6 | 2025 |
1 to 10 of 1,333Source NIH's project files
See all 1,333 nih grantsPapers2,085
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A dual A-to-Y and G-to-Y base editor and a four-base concurrent hypermutator in mammalian cells. | Nat Commun | 2026 | 42806035 | PubTator, text mining | PubMed |
| Multi-Omics Analysis Identifies TTYH3 and MPG as Candidate Osteoporosis-Associated Biomarkers in Osteoblasts and Characterizes Spatial Heterogeneity of SPP1 in the Osteoporotic Bone Microenvironment. | Biomedicines | 2026 | 42792867 | PubTator, text mining | PubMed |
| Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity. | Genes Dev | 2026 | 42722433 | PubTator, text mining | PubMed |
| Activity of natural single nucleotide variants of human alkyladenine DNA glycosylase AAG R145H, G163S and R197C involved in DNA binding. | Biochim Biophys Acta Proteins Proteom | 2026 | 42665032 | PubTator, text mining | PubMed |
| Substrate-Specific Inactivation of Human AAG by Tumor-Associated Single Nucleotide Polymorphic Variants. | Int J Mol Sci | 2026 | 42589254 | PubTator, text mining | PubMed |
| UV-DDB as a Dynamic Regulator Linking Base Excision and Nucleotide Excision Repair via AAG Interaction. | Int J Mol Sci | 2026 | 42353235 | PubTator, text mining | PubMed |
| The role and therapeutic potential of DNA glycosylases in Alzheimer's disease. | Ageing Res Rev | 2026 | 41956137 | PubTator, text mining | PubMed |
| A Rare Case of De Novo α-Globin Cluster Duplication, ααα102 (NC_000016.10: G.79903_181947dup) in a β-Thalassemia IVS 1-1 (G>T) (HBB: C.92 + 1G>T) Carrier with Thalassemia Intermedia Phenotype. | Hemoglobin | 2026 | 41956117 | PubTator, text mining | PubMed |
| Mechanisms of blood-brain barrier penetration: A molecular dynamics study on R9 and MPG peptide translocation. | Biochim Biophys Acta Biomembr | 2026 | 41875963 | PubTator, text mining | PubMed |
| Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome. | JCI Insight | 2026 | 41869725 | PubTator, text mining | PubMed |
1 to 10 of 2,085
See all 2,085 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4350
GET https://conductscience.org/api/genes/v1/4350/patents?page=2