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Gene · 4350

MPG: N-methylpurine DNA glycosylase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MPG: N-methylpurine DNA glycosylase. Genes, record 4350. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4350

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Gene

Symbol
MPG
HGNC
Name
N-methylpurine DNA glycosylase
HGNC
NCBI Gene ID
4350
NCBI Gene
HGNC ID
HGNC:7211
HGNC
Ensembl
ENSG00000103152
NCBI Gene
Aliases
AAG, ADPG, APNG, CRA36.1, MDG, PIG11, PIG16, anpg
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29372DNA-3-methyladenine glycosylase2989Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12624353 B22026-05-123938P29372Espacenet
US 12624354 B22026-05-123938P29372Espacenet
US 12570972 B22026-03-103938P29372Espacenet
US 12509680 B22025-12-303938P29372Espacenet
US 12281303 B22025-04-223938P29372Espacenet
EP 4522738 A12025-03-191P29372Espacenet
JP 2024542790 A2024-11-15200P29372Espacenet
JP 2024123008 A2024-09-107362P29372Espacenet
JP 2024530487 A2024-08-21134P29372Espacenet
US 12043827 B22024-07-2384P29372Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,333

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMPG papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines162025
P30CA047904Cancer Center Support Grant132025
P30ES010126UNC Center for Environmental Health and Susceptibility92025
P30CA033572Cancer Center Support Grant72025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant72025
P30CA068485Cancer Center Support Grant72025
P30CA014051Cancer Center Support (Core) Grant62025
P42ES027707The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous Chemicals62025
R35ES031638Watching cooperative interactions between base and nucleotide excision repair proteins62025
T32ES007028Training Program in Environmental Toxicology62025

1 to 10 of 1,333Source NIH's project files

See all 1,333 nih grants

Papers2,085

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A dual A-to-Y and G-to-Y base editor and a four-base concurrent hypermutator in mammalian cells.Nat Commun202642806035PubTator, text miningPubMed
Multi-Omics Analysis Identifies TTYH3 and MPG as Candidate Osteoporosis-Associated Biomarkers in Osteoblasts and Characterizes Spatial Heterogeneity of SPP1 in the Osteoporotic Bone Microenvironment.Biomedicines202642792867PubTator, text miningPubMed
Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity.Genes Dev202642722433PubTator, text miningPubMed
Activity of natural single nucleotide variants of human alkyladenine DNA glycosylase AAG R145H, G163S and R197C involved in DNA binding.Biochim Biophys Acta Proteins Proteom202642665032PubTator, text miningPubMed
Substrate-Specific Inactivation of Human AAG by Tumor-Associated Single Nucleotide Polymorphic Variants.Int J Mol Sci202642589254PubTator, text miningPubMed
UV-DDB as a Dynamic Regulator Linking Base Excision and Nucleotide Excision Repair via AAG Interaction.Int J Mol Sci202642353235PubTator, text miningPubMed
The role and therapeutic potential of DNA glycosylases in Alzheimer's disease.Ageing Res Rev202641956137PubTator, text miningPubMed
A Rare Case of De Novo α-Globin Cluster Duplication, ααα102 (NC_000016.10: G.79903_181947dup) in a β-Thalassemia IVS 1-1 (G>T) (HBB: C.92 + 1G>T) Carrier with Thalassemia Intermedia Phenotype.Hemoglobin202641956117PubTator, text miningPubMed
Mechanisms of blood-brain barrier penetration: A molecular dynamics study on R9 and MPG peptide translocation.Biochim Biophys Acta Biomembr202641875963PubTator, text miningPubMed
Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome.JCI Insight202641869725PubTator, text miningPubMed

1 to 10 of 2,085

See all 2,085 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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