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MPL: MPL proto-oncogene, thrombopoietin receptor

1 protein, 96 patents, 9 drugs, 283 trials, 2,049 NIH grants and 7,702 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMPLHGNC
NameMPL proto-oncogene, thrombopoietin receptorHGNC
NCBI Gene ID4352NCBI Gene
HGNC IDHGNC:7217HGNC
EnsemblENSG00000117400NCBI Gene
AliasesC-MPL, CD110, MPLV, THCYT2, THPOR, TPORNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P40238Thrombopoietin receptor6351Ensembl, GeneID, HGNCUniProt

Patents 96

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454489P40238Espacenet
EP 4650780 A22025-11-199108P40238Espacenet
WO 2025228986 A12025-11-0650P40238Espacenet
EP 4644537 A12025-11-0550P40238Espacenet
JP 2025147176 A2025-10-0616788P40238Espacenet
JP 2025529142 A2025-09-042681P40238Espacenet
US 12371689 B22025-07-292681P40238Espacenet
JP 2025517970 A2025-06-129108P40238Espacenet
WO 2025096560 A12025-05-0850P40238Espacenet
WO 2025096594 A22025-05-0850P40238Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVATROMBOPAGCHEMBL2103883Thrombopoietin receptor agonistAGONISTChEMBL
AVATROMBOPAG MALEATECHEMBL2105758Thrombopoietin receptor agonistAGONISTChEMBL
ELTROMBOPAGCHEMBL461101Thrombopoietin receptor agonistAGONISTChEMBL
ELTROMBOPAG CHOLINECHEMBL6068328Thrombopoietin receptor agonistAGONISTChEMBL
ELTROMBOPAG OLAMINECHEMBL3989691Thrombopoietin receptor agonistAGONISTChEMBL
HETROMBOPAG OLAMINECHEMBL4297764Thrombopoietin receptor agonistAGONISTChEMBL
LUSUTROMBOPAGCHEMBL2107831Thrombopoietin receptor agonistAGONISTChEMBL
RAFUTROMBOPAGCHEMBL4594401Thrombopoietin receptor agonistAGONISTChEMBL
ROMIPLOSTIMCHEMBL1201832Thrombopoietin receptor agonistAGONISTChEMBL

Trials 283

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07586826ROMIPLOSTIMPHASE2ClinicalTrials.gov
NCT07586813ROMIPLOSTIMPHASE2ClinicalTrials.gov
NCT07572084ROMIPLOSTIMPHASE2ClinicalTrials.gov
NCT07558434ROMIPLOSTIMPHASE2ClinicalTrials.gov
NCT07558434RAFUTROMBOPAGPHASE2ClinicalTrials.gov
NCT07558434ELTROMBOPAGPHASE2ClinicalTrials.gov
NCT07532408ROMIPLOSTIMPHASE2ClinicalTrials.gov
NCT07523009ROMIPLOSTIMPHASE2ClinicalTrials.gov
NCT07523009RAFUTROMBOPAGPHASE2ClinicalTrials.gov
NCT07523009ELTROMBOPAGPHASE2ClinicalTrials.gov

NIH grants 2049

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1152,025NIH's project files
P30CA008748Cancer Center Support Grant772,025NIH's project files
P01CA108671Myeloproliferative Neoplasms-Research Consortium612,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award142,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant122,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA122,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant122,025NIH's project files
ZIAHL002315Immune Pathophysiology of Aplastic Anemia and Immunosuppressive Treatments122,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias92,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center92,025NIH's project files

Papers 7702

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824004PubTator, text miningPubMed
42820873PubTator, text miningPubMed
42812491PubTator, text miningPubMed
42811375PubTator, text miningPubMed
42792882PubTator, text miningPubMed
42792816PubTator, text miningPubMed
42786200PubTator, text miningPubMed
42781284PubTator, text miningPubMed
42774674PubTator, text miningPubMed
42773742PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license